Search Results
Overview
| Uniprot ID | O95834 |
|---|---|
| Protein Name | Echinoderm microtubule-associated protein-like 2 |
| Gene Name | EML2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | SFGAGKTKEVIFSVE |
| 399 | FVTCGQDKLVHLWSS |
Function
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules
Protein Sequence
10
MSSFGAGKTK
20
EVIFSVEDGS
30
VKMFLRGRPV
40
PMMIPDELAP
50
TYSLDTRSEL
60
PSCRLKLEWV
70
YGYRGRDCRA
80
NLYLLPTGEI
90
VYFVASVAVL
100
YSVEEQRQRH
110
YLGHNDDIKC
120
LAIHPDMVTI
130
ATGQVAGTTK
140
EGKPLPPHVR
150
IWDSVSLSTL
160
HVLGLGVFDR
170
AVCCVGFSKS
180
NGGNLLCAVD
190
ESNDHMLSVW
200
DWAKETKVVD
210
VKCSNEAVLV
220
ATFHPTDPTV
230
LITCGKSHIY
240
FWTLEGGSLS
250
KRQGLFEKHE
260
KPKYVLCVTF
270
LEGGDVVTGD
280
SGGNLYVWGK
290
GGNRITQAVL
300
GAHDGGVFGL
310
CALRDGTLVS
320
GGGRDRRVVL
330
WGSDYSKLQE
340
VEVPEDFGPV
350
RTVAEGHGDT
360
LYVGTTRNSI
370
LQGSVHTGFS
380
LLVQGHVEEL
390
WGLATHPSRA
400
QFVTCGQDKL
410
VHLWSSDSHQ
420
PLWSRIIEDP
430
ARSAGFHPSG
440
SVLAVGTVTG
450
RWLLLDTETH
460
DLVAIHTDGN
470
EQISVVSFSP
480
DGAYLAVGSH
490
DNLVYVYTVD
500
QGGRKVSRLG
510
KCSGHSSFIT
520
HLDWAQDSSC
530
FVTNSGDYEI
540
LYWDPATCKQ
550
ITSADAVRNM
560
EWATATCVLG
570
FGVFGIWSEG
580
ADGTDINAVA
590
RSHDGKLLAS
600
ADDFGKVHLF
610
SYPCCQPRAL
620
SHKYGGHSSH
630
VTNVAFLWDD
640
SMALTTGGKD
TSVLQWRVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0010968 | regulation of microtubule nucleation |
| Biological Process | GO:0007605 | sensory perception of sound |
| Biological Process | GO:0007601 | visual perception |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.