Overview
| Uniprot ID | O95861 |
|---|
| Protein Name | 3'(2'),5'-bisphosphate nucleotidase 1 |
|---|
| Gene Name | BPNT1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 189 |
LKEVPAGKHIITTTR |
| 201 |
TTRSHSNKLVTDCVA |
| 274 |
GNVLQYHKDVKHMNS |
| 49 |
CATDLQTKADRLAQM |
Function
Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562)
Protein Sequence
10
MASSNTVLMR
20
LVASAYSIAQ
30
KAGMIVRRVI
40
AEGDLGIVEK
50
TCATDLQTKA
60
DRLAQMSICS
70
SLARKFPKLT
80
IIGEEDLPSE
90
EVDQELIEDS
100
QWEEILKQPC
110
PSQYSAIKEE
120
DLVVWVDPLD
130
GTKEYTEGLL
140
DNVTVLIGIA
150
YEGKAIAGVI
160
NQPYYNYEAG
170
PDAVLGRTIW
180
GVLGLGAFGF
190
QLKEVPAGKH
200
IITTTRSHSN
210
KLVTDCVAAM
220
NPDAVLRVGG
230
AGNKIIQLIE
240
GKASAYVFAS
250
PGCKKWDTCA
260
PEVILHAVGG
270
KLTDIHGNVL
280
QYHKDVKHMN
290
SAGVLATLRN
300
YDYYASRVPE
SIKNALVP
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0008441 |
3'(2'),5'-bisphosphate nucleotidase activity |
| Molecular Function |
GO:0004441 |
inositol-1,4-bisphosphate 1-phosphatase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0006139 |
nucleobase-containing compound metabolic process |
| Biological Process |
GO:0046854 |
phosphatidylinositol phosphate biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.