Search Results
Overview
| Uniprot ID | O95936 |
|---|---|
| Protein Name | Eomesodermin homolog |
| Gene Name | EOMES |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 641 | GVYTSACKRRRLSPS |
Function
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017)
Protein Sequence
10
MQLGEQLLVS
20
SVNLPGAHFY
30
PLESARGGSG
40
GSAGHLPSAA
50
PSPQKLDLDK
60
ASKKFSGSLS
70
CEAVSGEPAA
80
ASAGAPAAML
90
SDTDAGDAFA
100
SAAAVAKPGP
110
PDGRKGSPCG
120
EEELPSAAAA
130
AAAAAAAAAA
140
TARYSMDSLS
150
SERYYLQSPG
160
PQGSELAAPC
170
SLFPYQAAAG
180
APHGPVYPAP
190
NGARYPYGSM
200
LPPGGFPAAV
210
CPPGRAQFGP
220
GAGAGSGAGG
230
SSGGGGGPGT
240
YQYSQGAPLY
250
GPYPGAAAAG
260
SCGGLGGLGV
270
PGSGFRAHVY
280
LCNRPLWLKF
290
HRHQTEMIIT
300
KQGRRMFPFL
310
SFNINGLNPT
320
AHYNVFVEVV
330
LADPNHWRFQ
340
GGKWVTCGKA
350
DNNMQGNKMY
360
VHPESPNTGS
370
HWMRQEISFG
380
KLKLTNNKGA
390
NNNNTQMIVL
400
QSLHKYQPRL
410
HIVEVTEDGV
420
EDLNEPSKTQ
430
TFTFSETQFI
440
AVTAYQNTDI
450
TQLKIDHNPF
460
AKGFRDNYDS
470
SHQIVPGGRY
480
GVQSFFPEPF
490
VNTLPQARYY
500
NGERTVPQTN
510
GLLSPQQSEE
520
VANPPQRWLV
530
TPVQQPGTNK
540
LDISSYESEY
550
TSSTLLPYGI
560
KSLPLQTSHA
570
LGYYPDPTFP
580
AMAGWGGRGS
590
YQRKMAAGLP
600
WTSRTSPTVF
610
SEDQLSKEKV
620
KEEIGSSWIE
630
TPPSIKSLDS
640
NDSGVYTSAC
650
KRRRLSPSNS
660
SNENSPSIKC
670
EDINAEEYSK
680
DTSKGMGGYY
AFYTTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0048708 | astrocyte differentiation |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response |
| Biological Process | GO:0060706 | cell differentiation involved in embryonic placenta development |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021895 | cerebral cortex neuron differentiation |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0001706 | endoderm formation |
| Biological Process | GO:0001714 | endodermal cell fate specification |
| Biological Process | GO:0001707 | mesoderm formation |
| Biological Process | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A