Search Results
Overview
| Uniprot ID | O95954 |
|---|---|
| Protein Name | Formimidoyltransferase-cyclodeaminase |
| Gene Name | FTCD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | GEYEALPKKLQQADW |
| 210 | LREQGRGKDQPGRLK |
| 218 | DQPGRLKKVQGIGWY |
| 318 | SLCPFSPKERIIEYL |
| 338 | PERGLGSKSLRAFVG |
| 427 | LEAMRLPKNTPEEKD |
| 433 | PKNTPEEKDRRTAAL |
| 511 | DITDEAFKDQIHHRV |
Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool
Protein Sequence
10
MSQLVECVPN
20
FSEGKNQEVI
30
DAISGAITQT
40
PGCVLLDVDA
50
GPSTNRTVYT
60
FVGPPECVVE
70
GALNAARVAS
80
RLIDMSRHQG
90
EHPRMGALDV
100
CPFIPVRGVS
110
VDECVLCAQA
120
FGQRLAEELD
130
VPVYLYGEAA
140
RMDSRRTLPA
150
IRAGEYEALP
160
KKLQQADWAP
170
DFGPSSFVPS
180
WGATATGARK
190
FLIAFNINLL
200
GTKEQAHRIA
210
LNLREQGRGK
220
DQPGRLKKVQ
230
GIGWYLDEKN
240
LAQVSTNLLD
250
FEVTALHTVY
260
EETCREAQEL
270
SLPVVGSQLV
280
GLVPLKALLD
290
AAAFYCEKEN
300
LFILEEEQRI
310
RLVVSRLGLD
320
SLCPFSPKER
330
IIEYLVPERG
340
PERGLGSKSL
350
RAFVGEVGAR
360
SAAPGGGSVA
370
AAAAAMGAAL
380
GSMVGLMTYG
390
RRQFQSLDTT
400
MRRLIPPFRE
410
ASAKLTTLVD
420
ADAEAFTAYL
430
EAMRLPKNTP
440
EEKDRRTAAL
450
QEGLRRAVSV
460
PLTLAETVAS
470
LWPALQELAR
480
CGNLACRSDL
490
QVAAKALEMG
500
VFGAYFNVLI
510
NLRDITDEAF
520
KDQIHHRVSS
530
LLQEAKTQAA
540
LVLDCLETRQ
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030868 | smooth endoplasmic reticulum membrane |
| Molecular Function | GO:0005542 | folic acid binding |
| Molecular Function | GO:0030412 | formimidoyltetrahydrofolate cyclodeaminase activity |
| Molecular Function | GO:0030409 | glutamate formimidoyltransferase activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0006760 | folic acid-containing compound metabolic process |
| Biological Process | GO:0019556 | L-histidine catabolic process to glutamate and formamide |
| Biological Process | GO:0019557 | L-histidine catabolic process to glutamate and formate |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.