Search Results
Overview
| Uniprot ID | O95994 |
|---|---|
| Protein Name | Anterior gradient protein 2 homolog |
| Gene Name | AGR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 39 | DTKDSRPKLPQTLSR |
| 89 | PHSQALKKVFAENKE |
| 95 | KKVFAENKEIQKLAE |
Function
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113)
Protein Sequence
10
MEKIPVSAFL
20
LLVALSYTLA
30
RDTTVKPGAK
40
KDTKDSRPKL
50
PQTLSRGWGD
60
QLIWTQTYEE
70
ALYKSKTSNK
80
PLMIIHHLDE
90
CPHSQALKKV
100
FAENKEIQKL
110
AEQFVLLNLV
120
YETTDKHLSP
130
DGQYVPRIMF
140
VDPSLTVRAD
150
ITGRYSNRLY
160
AYEPADTALL
170
LDNMKKALKL
LKTEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0005154 | epidermal growth factor receptor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0048546 | digestive tract morphogenesis |
| Biological Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0070254 | mucus secretion |
| Biological Process | GO:0010811 | positive regulation of cell-substrate adhesion |
| Biological Process | GO:0048639 | positive regulation of developmental growth |
| Biological Process | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| Biological Process | GO:1903899 | positive regulation of PERK-mediated unfolded protein response |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0034975 | protein folding in endoplasmic reticulum |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.