Search Results

Overview

Uniprot IDO95996
Protein NameAdenomatous polyposis coli protein 2
Gene NameAPC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1444 QAMGHRHKAGGAGRS

Function

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329)

Protein Sequence

10 MASSVAPYEQ 20 LVRQVEALKA 30 ENSHLRQELR 40 DNSSHLSKLE 50 TETSGMKEVL 60 KHLQGKLEQE 70 ARVLVSSGQT 80 EVLEQLKALQ 90 MDITSLYNLK 100 FQPPTLGPEP 110 AARTPEGSPV 120 HGSGPSKDSF 130 GELSRATIRL 140 LEELDRERCF 150 LLNEIEKEEK 160 EKLWYYSQLQ 170 GLSKRLDELP 180 HVETQFSMQM 190 DLIRQQLEFE 200 AQHIRSLMEE 210 RFGTSDEMVQ 220 RAQIRASRLE 230 QIDKELLEAQ 240 DRVQQTEPQA 250 LLAVKSVPVD 260 EDPETEVPTH 270 PEDGTPQPGN 280 SKVEVVFWLL 290 SMLATRDQED 300 TARTLLAMSS 310 SPESCVAMRR 320 SGCLPLLLQI 330 LHGTEAAAGG 340 RAGAPGAPGA 350 KDARMRANAA 360 LHNIVFSQPD 370 QGLARKEMRV 380 LHVLEQIRAY 390 CETCWDWLQA 400 RDGGPEGGGA 410 GSAPIPIEPQ 420 ICQATCAVMK 430 LSFDEEYRRA 440 MNELGGLQAV 450 AELLQVDYEM 460 HKMTRDPLNL 470 ALRRYAGMTL 480 TNLTFGDVAN 490 KATLCARRGC 500 MEAIVAQLAS 510 DSEELHQVVS 520 SILRNLSWRA 530 DINSKKVLRE 540 AGSVTALVQC 550 VLRATKESTL 560 KSVLSALWNL 570 SAHSTENKAA 580 ICQVDGALGF 590 LVSTLTYKCQ 600 SNSLAIIESG 610 GGILRNVSSL 620 VATREDYRQV 630 LRDHNCLQTL 640 LQHLTSHSLT 650 IVSNACGTLW 660 NLSARSARDQ 670 ELLWDLGAVG 680 MLRNLVHSKH 690 KMIAMGSAAA 700 LRNLLAHRPA 710 KHQAAATAVS 720 PGSCVPSLYV 730 RKQRALEAEL 740 DARHLAQALE 750 HLEKQGPPAA 760 EAATKKPLPP 770 LRHLDGLAQD 780 YASDSGCFDD 790 DDAPSSLAAA 800 AATGEPASPA 810 ALSLFLGSPF 820 LQGQALARTP 830 PTRRGGKEAE 840 KDTSGEAAVA 850 AKAKAKLALA 860 VARIDQLVED 870 ISALHTSSDD 880 SFSLSSGDPG 890 QEAPREGRAQ 900 SCSPCRGPEG 910 GRREAGSRAH 920 PLLRLKAAHA 930 SLSNDSLNSG 940 SASDGYCPRE 950 HMLPCPLAAL 960 ASRREDPRCG 970 QPRPSRLDLD 980 LPGCQAEPPA 990 REATSADARV 1000 RTIKLSPTYQ 1010 HVPLLEGASR 1020 AGAEPLAGPG 1030 ISPGARKQAW 1040 LPADHLSKVP 1050 EKLAAAPLSV 1060 ASKALQKLAA 1070 QEGPLSLSRC 1080 SSLSSLSSAG 1090 RPGPSEGGDL 1100 DDSDSSLEGL 1110 EEAGPSEAEL 1120 DSTWRAPGAT 1130 SLPVAIPAPR 1140 RNRGRGLGVE 1150 DATPSSSSEN 1160 YVQETPLVLS 1170 RCSSVSSLGS 1180 FESPSIASSI 1190 PSEPCSGQGS 1200 GTISPSELPD 1210 SPGQTMPPSR 1220 SKTPPLAPAP 1230 QGPPEATQFS 1240 LQWESYVKRF 1250 LDIADCRERC 1260 RLPSELDAGS 1270 VRFTVEKPDE 1280 NFSCASSLSA 1290 LALHEHYVQQ 1300 DVELRLLPSA 1310 CPERGGGAGG 1320 AGLHFAGHRR 1330 REEGPAPTGS 1340 RPRGAADQEL 1350 ELLRECLGAA 1360 VPARLRKVAS 1370 ALVPGRRALP 1380 VPVYMLVPAP 1390 APAQEDDSCT 1400 DSAEGTPVNF 1410 SSAASLSDET 1420 LQGPPRDQPG 1430 GPAGRQRPTG 1440 RPTSARQAMG 1450 HRHKAGGAGR 1460 SAEQSRGAGK 1470 NRAGLELPLG 1480 RPPSAPADKD 1490 GSKPGRTRGD 1500 GALQSLCLTT 1510 PTEEAVYCFY 1520 GNDSDEEPPA 1530 AAPTPTHRRT 1540 SAIPRAFTRE 1550 RPQGRKEAPA 1560 PSKAAPAAPP 1570 PARTQPSLIA 1580 DETPPCYSLS 1590 SSASSLSEPE 1600 PSEPPAVHPR 1610 GREPAVTKDP 1620 GPGGGRDSSP 1630 SPRAAEELLQ 1640 RCISSALPRR 1650 RPPVSGLRRR 1660 KPRATRLDER 1670 PAEGSRERGE 1680 EAAGSDRASD 1690 LDSVEWRAIQ 1700 EGANSIVTWL 1710 HQAAAATREA 1720 SSESDSILSF 1730 VSGLSVGSTL 1740 QPPKHRKGRQ 1750 AEGEMGSARR 1760 PEKRGAASVK 1770 TSGSPRSPAG 1780 PEKPRGTQKT 1790 TPGVPAVLRG 1800 RTVIYVPSPA 1810 PRAQPKGTPG 1820 PRATPRKVAP 1830 PCLAQPAAPA 1840 KVPSPGQQRS 1850 RSLHRPAKTS 1860 ELATLSQPPR 1870 SATPPARLAK 1880 TPSSSSSQTS 1890 PASQPLPRKR 1900 PPVTQAAGAL 1910 PGPGASPVPK 1920 TPARTLLAKQ 1930 HKTQRSPVRI 1940 PFMQRPARRG 1950 PPPLARAVPE 1960 PGPRGRAGTE 1970 AGPGARGGRL 1980 GLVRVASALS 1990 SGSESSDRSG 2000 FRRQLTFIKE 2010 SPGLRRRRSE 2020 LSSAESAASA 2030 PQGASPRRGR 2040 PALPAVFLCS 2050 SRCEELRAAP 2060 RQGPAPARQR 2070 PPAARPSPGE 2080 RPARRTTSES 2090 PSRLPVRAPA 2100 ARPETVKRYA 2110 SLPHISVARR 2120 PDGAVPAAPA 2130 SADAARRSSD 2140 GEPRPLPRVA 2150 APGTTWRRIR 2160 DEDVPHILRS 2170 TLPATALPLR 2180 GSTPEDAPAG 2190 PPPRKTSDAV 2200 VQTEEVAAPK 2210 TNSSTSPSLE 2220 TREPPGAPAG 2230 GQLSLLGSDV 2240 DGPSLAKAPI 2250 SAPFVHEGLG 2260 VAVGGFPASR 2270 HGSPSRSARV 2280 PPFNYVPSPM 2290 VVAATTDSAA 2300 EKAPATASAT LLE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Biological Process GO:0007399 nervous system development
Biological Process GO:0007389 pattern specification process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016055 Wnt signaling pathway
Cellular Component GO:0030877 beta-catenin destruction complex
Cellular Component GO:0016342 catenin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0031258 lamellipodium membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0045295 gamma-catenin binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0001708 cell fate specification
Biological Process GO:0016477 cell migration
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0007026 negative regulation of microtubule depolymerization

Reference

PMID: N/A