Overview
| Uniprot ID | O95997 |
|---|
| Protein Name | Securin |
|---|
| Gene Name | PTTG1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 25 |
VVAKDGLKLGSGPSI |
| 58 |
DAPPALPKATRKALG |
| 62 |
ALPKATRKALGTVNR |
Function
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation
Protein Sequence
10
MATLIYVDKE
20
NGEPGTRVVA
30
KDGLKLGSGP
40
SIKALDGRSQ
50
VSTPRFGKTF
60
DAPPALPKAT
70
RKALGTVNRA
80
TEKSVKTKGP
90
LKQKQPSFSA
100
KKMTEKTVKA
110
KSSVPASDDA
120
YPEIEKFFPF
130
NPLDFESFDL
140
PEEHQIAHLP
150
LSGVPLMILD
160
EERELEKLFQ
170
LGPPSPVKMP
180
SPPWESNLLQ
190
SPSSILSTLD
200
VELPPVCCDI
DI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
| Molecular Function |
GO:0140677 |
molecular function activator activity |
| Molecular Function |
GO:0017124 |
SH3 domain binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0051276 |
chromosome organization |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0045143 |
homologous chromosome segregation |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.