Overview
| Uniprot ID | O96005 |
|---|
| Protein Name | Putative lipid scramblase CLPTM1 |
|---|
| Gene Name | CLPTM1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 460 |
PRLSFKDKSTYIESS |
Function
Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity)
Protein Sequence
10
MAAAQEADGA
20
RSAVVAAGGG
30
SSGQVTSNGS
40
IGRDPPAETQ
50
PQNPPAQPAP
60
NAWQVIKGVL
70
FRIFIIWAIS
80
SWFRRGPAPQ
90
DQAGPGGAPR
100
VASRNLFPKD
110
TLMNLHVYIS
120
EHEHFTDFNA
130
TSALFWEQHD
140
LVYGDWTSGE
150
NSDGCYEHFA
160
ELDIPQSVQQ
170
NGSIYIHVYF
180
TKSGFHPDPR
190
QKALYRRLAT
200
VHMSRMINKY
210
KRRRFQKTKN
220
LLTGETEADP
230
EMIKRAEDYG
240
PVEVISHWHP
250
NITINIVDDH
260
TPWVKGSVPP
270
PLDQYVKFDA
280
VSGDYYPIIY
290
FNDYWNLQKD
300
YYPINESLAS
310
LPLRVSFCPL
320
SLWRWQLYAA
330
QSTKSPWNFL
340
GDELYEQSDE
350
EQDSVKVALL
360
ETNPYLLALT
370
IIVSIVHSVF
380
EFLAFKNDIQ
390
FWNSRQSLEG
400
LSVRSVFFGV
410
FQSFVVLLYI
420
LDNETNFVVQ
430
VSVFIGVLID
440
LWKITKVMDV
450
RLDREHRVAG
460
IFPRLSFKDK
470
STYIESSTKV
480
YDDMAFRYLS
490
WILFPLLGCY
500
AVYSLLYLEH
510
KGWYSWVLSM
520
LYGFLLTFGF
530
ITMTPQLFIN
540
YKLKSVAHLP
550
WRMLTYKALN
560
TFIDDLFAFV
570
IKMPVMYRIG
580
CLRDDVVFFI
590
YLYQRWIYRV
600
DPTRVNEFGM
610
SGEDPTAAAP
620
VAEVPTAAGA
630
LTPTPAPTTT
640
TATREEASTS
650
LPTKPTQGAS
660
SASEPQEAPP
KPAEDKKKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0050811 |
GABA receptor binding |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0033081 |
regulation of T cell differentiation in thymus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.