Search Results
Overview
| Uniprot ID | O96006 |
|---|---|
| Protein Name | E3 SUMO-protein ligase ZBED1 |
| Gene Name | ZBED1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 96 | AFATAFSKLKPESSQ |
Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747)
Protein Sequence
10
MENKSLESSQ
20
TDLKLVAHPR
30
AKSKVWKYFG
40
FDTNAEGCIL
50
QWKKIYCRIC
60
MAQIAYSGNT
70
SNLSYHLEKN
80
HPEEFCEFVK
90
SNTEQMREAF
100
ATAFSKLKPE
110
SSQQPGQDAL
120
AVKAGHGYDS
130
KKQQELTAAV
140
LGLICEGLYP
150
ASIVDEPTFK
160
VLLKTADPRY
170
ELPSRKYIST
180
KAIPEKYGAV
190
REVILKELAE
200
ATWCGISTDM
210
WRSENQNRAY
220
VTLAAHFLGL
230
GAPNCLSMGS
240
RCLKTFEVPE
250
ENTAETITRV
260
LYEVFIEWGI
270
SAKVFGATTN
280
YGKDIVKACS
290
LLDVAVHMPC
300
LGHTFNAGIQ
310
QAFQLPKLGA
320
LLSRCRKLVE
330
YFQQSAVAMY
340
MLYEKQKQQN
350
VAHCMLVSNR
360
VSWWGSTLAM
370
LQRLKEQQFV
380
IAGVLVEDSN
390
NHHLMLEASE
400
WATIEGLVEL
410
LQPFKQVAEM
420
LSASRYPTIS
430
MVKPLLHMLL
440
NTTLNIKETD
450
SKELSMAKEV
460
IAKELSKTYQ
470
ETPEIDMFLN
480
VATFLDPRYK
490
RLPFLSAFER
500
QQVENRVVEE
510
AKGLLDKVKD
520
GGYRPAEDKI
530
FPVPEEPPVK
540
KLMRTSTPPP
550
ASVINNMLAE
560
IFCQTGGVED
570
QEEWHAQVVE
580
ELSNFKSQKV
590
LGLNEDPLKW
600
WSDRLALFPL
610
LPKVLQKYWC
620
VTATRVAPER
630
LFGSAANVVS
640
AKRNRLAPAH
650
VDEQVFLYEN
660
ARSGAEAEPE
670
DQDEGEWGLD
680
QEQVFSLGDG
690
VSGGFFGIRD
SSFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016605 | PML body |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0061665 | SUMO ligase activity |
| Molecular Function | GO:0019789 | SUMO transferase activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0044828 | host-mediated suppression of viral genome replication |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1990466 | protein autosumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A