Search Results
Overview
| Uniprot ID | O97580 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
| Gene Name | SUCLA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 379 | GTRVDDAKALIADSG |
| 50 | DEAYAIAKKLGSKDV |
| 78 | GTFESGLKGGVKIVF |
| 82 | SGLKGGVKIVFSPEE |
Function
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase
Protein Sequence
10
NNHGLQIQQQ
20
QQRNLSLHEY
30
MSMELLQEAG
40
VSIPKGHVAK
50
SPDEAYAIAK
60
KLGSKDVVIK
70
AQVLAGGRGK
80
GTFESGLKGG
90
VKIVFSPEEA
100
KAVSSQMIGK
110
KLFTKQTGEK
120
GRICNQVLVC
130
ERRYPRREYY
140
FAITMERSFQ
150
GPVLIGSSQG
160
GVNIEDVAAE
170
TPEAIVKEPI
180
DIVEGIKKEQ
190
AVRLAQKMGF
200
PPSIVDSAAE
210
NMIKLYNLFL
220
KYDATMVEIN
230
PMVEDSDGAV
240
LCMDAKINFD
250
SNSAYRQKKI
260
FDLQDWTQED
270
ERDKDAAKAN
280
LNYIGLDGNI
290
GCLVNGAGLA
300
MATMDIIKLH
310
GGTPANFLDV
320
GGGATVHQVT
330
EAFKLITSDK
340
KVLSILVNIF
350
GGIMRCDVIA
360
QGIVMAVKDL
370
EIKIPVVVRL
380
QGTRVDDAKA
390
LIADSGLKIL
400
ACDDLDEAAK
410
MVVKLSEIVT
420
LTKQAQVDVK
FQLPI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0042709 | succinate-CoA ligase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0050074 | malate-CoA ligase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.