Search Results

Overview

Uniprot IDP00338
Protein NameL-lactate dehydrogenase A chain
Gene NameLDHA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
118 QRNVNIFKFIIPNVV
126 FIIPNVVKYSPNCKL
14 QLIYNLLKEEQTPQN
222 HPDLGTDKDKEQWKE
228 DKDKEQWKEVHKQVV
232 EQWKEVHKQVVESAY
243 ESAYEVIKLKGYTSW
278 HPVSTMIKGLYGIKD
318 EEEARLKKSADTLWG
5 ***MATLKDQLIYNL
59 DVIEDKLKGEMMDLQ
76 SLFLRTPKIVSGKDY
81 TPKIVSGKDYNVTAN

Function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

Protein Sequence

10 MATLKDQLIY 20 NLLKEEQTPQ 30 NKITVVGVGA 40 VGMACAISIL 50 MKDLADELAL 60 VDVIEDKLKG 70 EMMDLQHGSL 80 FLRTPKIVSG 90 KDYNVTANSK 100 LVIITAGARQ 110 QEGESRLNLV 120 QRNVNIFKFI 130 IPNVVKYSPN 140 CKLLIVSNPV 150 DILTYVAWKI 160 SGFPKNRVIG 170 SGCNLDSARF 180 RYLMGERLGV 190 HPLSCHGWVL 200 GEHGDSSVPV 210 WSGMNVAGVS 220 LKTLHPDLGT 230 DKDKEQWKEV 240 HKQVVESAYE 250 VIKLKGYTSW 260 AIGLSVADLA 270 ESIMKNLRRV 280 HPVSTMIKGL 290 YGIKDDVFLS 300 VPCILGQNGI 310 SDLVKVTLTS 320 EEEARLKKSA 330 DTLWGIQKEL QF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035686 sperm fibrous sheath
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004459 L-lactate dehydrogenase (NAD+) activity
Biological Process GO:0006096 glycolytic process
Biological Process GO:0006089 lactate metabolic process
Biological Process GO:0042867 pyruvate catabolic process
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.