Search Results
Overview
| Uniprot ID | P00348 |
|---|---|
| Protein Name | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
| Gene Name | HADH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 206 | DFSKTLGKHPVSCKD |
| 212 | GKHPVSCKDTPGFIV |
| 301 | NKLVAENKFGKKTGE |
| 312 | KTGEGFYKYK***** |
| 87 | KKFAENPKAGDEFVE |
Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:2817332, PubMed:9593854). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity)
Protein Sequence
10
MAFATRQLVR
20
SLSSSSTAAA
30
SAKKILVKHV
40
TVIGGGLMGA
50
GIAQVAAATG
60
HTVVLVDQTE
70
DILAKSKKGI
80
EESLRKVAKK
90
KFAENPKAGD
100
EFVEKTLSSI
110
STSTDAASVV
120
HSTDLVVEAI
130
VENLKVKSEL
140
FKRLDKFAAE
150
HTIFASNTSS
160
LQITSLANAT
170
TRQDRFAGLH
180
FFNPVPLMKL
190
VEVVKTPMTS
200
QKTLESLVDF
210
SKTLGKHPVS
220
CKDTPGFIVN
230
RLLVPYLIEA
240
VRLYERGDAS
250
KEDIDTAMKL
260
GAGYPMGPFE
270
LLDYVGLDTT
280
KFIIDGWHEM
290
DSQNPLFQPS
300
PAMNKLVAEN
310
KFGKKTGEGF
YKYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003857 | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070403 | NAD+ binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0050796 | regulation of insulin secretion |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.