Search Results

Overview

Uniprot IDP00352
Protein NameAldehyde dehydrogenase 1A1
Gene NameALDH1A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
139 YCAGWADKIQGRTIP
22 DLKIQYTKIFINNEW
252 TGSTEVGKLIKEAAG
255 TEVGKLIKEAAGKSN
260 LIKEAAGKSNLKRVT
329 RSVERAKKYILGNPL
348 TQGPQIDKEQYDKIL
36 WHDSVSGKKFPVFNP
362 LDLIESGKKEGAKLE
367 SGKKEGAKLECGGGP
37 HDSVSGKKFPVFNPA
398 TDEMRIAKEEIFGPV
410 GPVQQIMKFKSLDDV
412 VQQIMKFKSLDDVIK
419 KSLDDVIKRANNTFY
435 LSAGVFTKDIDKAIT
490 FHEYTEVKTVTVKIS
495 EVKTVTVKISQKNS*
62 GDKEDVDKAVKAARQ
91 ERGRLLYKLADLIER

Function

Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694, PubMed:25413692). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:25413692). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (PubMed:25413692). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity)

Protein Sequence

10 MSSSGTPDLP 20 VLLTDLKIQY 30 TKIFINNEWH 40 DSVSGKKFPV 50 FNPATEEELC 60 QVEEGDKEDV 70 DKAVKAARQA 80 FQIGSPWRTM 90 DASERGRLLY 100 KLADLIERDR 110 LLLATMESMN 120 GGKLYSNAYL 130 NDLAGCIKTL 140 RYCAGWADKI 150 QGRTIPIDGN 160 FFTYTRHEPI 170 GVCGQIIPWN 180 FPLVMLIWKI 190 GPALSCGNTV 200 VVKPAEQTPL 210 TALHVASLIK 220 EAGFPPGVVN 230 IVPGYGPTAG 240 AAISSHMDID 250 KVAFTGSTEV 260 GKLIKEAAGK 270 SNLKRVTLEL 280 GGKSPCIVLA 290 DADLDNAVEF 300 AHHGVFYHQG 310 QCCIAASRIF 320 VEESIYDEFV 330 RRSVERAKKY 340 ILGNPLTPGV 350 TQGPQIDKEQ 360 YDKILDLIES 370 GKKEGAKLEC 380 GGGPWGNKGY 390 FVQPTVFSNV 400 TDEMRIAKEE 410 IFGPVQQIMK 420 FKSLDDVIKR 430 ANNTFYGLSA 440 GVFTKDIDKA 450 ITISSALQAG 460 TVWVNCYGVV 470 SAQCPFGGFK 480 MSGNGRELGE 490 YGFHEYTEVK 500 TVTVKISQKN S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0106373 3-deoxyglucosone dehydrogenase activity
Molecular Function GO:0140087 acetaldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0005497 androgen binding
Molecular Function GO:0018479 benzaldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0001758 retinal dehydrogenase (NAD+) activity
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0030392 fructosamine catabolic process
Biological Process GO:0009449 gamma-aminobutyric acid biosynthetic process
Biological Process GO:0036438 maintenance of lens transparency
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.