Search Results
Overview
| Uniprot ID | P00439 |
|---|---|
| Protein Name | Phenylalanine-4-hydroxylase |
| Gene Name | PAH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 159 | PVYRARRKQFADIAY |
| 50 | EEVGALAKVLRLFEE |
| 73 | ESRPSRLKKDEYEFF |
| 85 | EFFTHLDKRSLPALT |
Function
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine
Protein Sequence
10
MSTAVLENPG
20
LGRKLSDFGQ
30
ETSYIEDNCN
40
QNGAISLIFS
50
LKEEVGALAK
60
VLRLFEENDV
70
NLTHIESRPS
80
RLKKDEYEFF
90
THLDKRSLPA
100
LTNIIKILRH
110
DIGATVHELS
120
RDKKKDTVPW
130
FPRTIQELDR
140
FANQILSYGA
150
ELDADHPGFK
160
DPVYRARRKQ
170
FADIAYNYRH
180
GQPIPRVEYM
190
EEEKKTWGTV
200
FKTLKSLYKT
210
HACYEYNHIF
220
PLLEKYCGFH
230
EDNIPQLEDV
240
SQFLQTCTGF
250
RLRPVAGLLS
260
SRDFLGGLAF
270
RVFHCTQYIR
280
HGSKPMYTPE
290
PDICHELLGH
300
VPLFSDRSFA
310
QFSQEIGLAS
320
LGAPDEYIEK
330
LATIYWFTVE
340
FGLCKQGDSI
350
KAYGAGLLSS
360
FGELQYCLSE
370
KPKLLPLELE
380
KTAIQNYTVT
390
EFQPLYYVAE
400
SFNDAKEKVR
410
NFAATIPRPF
420
SVRYDPYTQR
430
IEVLDNTQQL
440
KILADSINSE
450
IGILCSALQK
IK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0004505 | phenylalanine 4-monooxygenase activity |
| Biological Process | GO:0008652 | amino acid biosynthetic process |
| Biological Process | GO:0042423 | catecholamine biosynthetic process |
| Biological Process | GO:0006559 | L-phenylalanine catabolic process |
| Biological Process | GO:0006571 | L-tyrosine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.