Search Results
Overview
| Uniprot ID | P00441 |
|---|---|
| Protein Name | Superoxide dismutase [Cu-Zn] |
| Gene Name | SOD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | TKAVCVLKGDGPVQG |
| 123 | RTLVVHEKADDLGKG |
| 129 | EKADDLGKGGNEEST |
| 137 | GGNEESTKTGNAGSR |
| 24 | GIINFEQKESNGPVK |
| 31 | KESNGPVKVWGSIKG |
| 37 | VKVWGSIKGLTEGLH |
| 4 | ****MATKAVCVLKG |
| 71 | HFNPLSRKHGGPKDE |
| 76 | SRKHGGPKDEERHVG |
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems (PubMed:18948262, PubMed:24140062). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides (PubMed:36630448)
Protein Sequence
10
MATKAVCVLK
20
GDGPVQGIIN
30
FEQKESNGPV
40
KVWGSIKGLT
50
EGLHGFHVHE
60
FGDNTAGCTS
70
AGPHFNPLSR
80
KHGGPKDEER
90
HVGDLGNVTA
100
DKDGVADVSI
110
EDSVISLSGD
120
HCIIGRTLVV
130
HEKADDLGKG
140
GNEESTKTGN
150
AGSRLACGVI
GIAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0060052 | neurofilament cytoskeleton organization |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0032287 | peripheral nervous system myelin maintenance |
| Biological Process | GO:0001890 | placenta development |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0001819 | positive regulation of cytokine production |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0072593 | reactive oxygen species metabolic process |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0043087 | regulation of GTPase activity |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0040014 | regulation of multicellular organism growth |
| Biological Process | GO:0046620 | regulation of organ growth |
| Biological Process | GO:0033081 | regulation of T cell differentiation in thymus |
| Biological Process | GO:0060087 | relaxation of vascular associated smooth muscle |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0097332 | response to antipsychotic drug |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0034465 | response to carbon monoxide |
| Biological Process | GO:0046688 | response to copper ion |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0000303 | response to superoxide |
| Biological Process | GO:0001895 | retina homeostasis |
| Biological Process | GO:0008090 | retrograde axonal transport |
| Biological Process | GO:0007605 | sensory perception of sound |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0006801 | superoxide metabolic process |
| Biological Process | GO:0048538 | thymus development |
| Biological Process | GO:0019226 | transmission of nerve impulse |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030346 | protein phosphatase 2B binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0004784 | superoxide dismutase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0060088 | auditory receptor cell stereocilium organization |
| Biological Process | GO:0071318 | cellular response to ATP |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:0007566 | embryo implantation |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0060047 | heart contraction |
| Biological Process | GO:0050665 | hydrogen peroxide biosynthetic process |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0002262 | myeloid cell homeostasis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.