Search Results
Overview
| Uniprot ID | P00480 |
|---|---|
| Protein Name | Ornithine transcarbamylase, mitochondrial |
| Gene Name | OTC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | AVLARVYKQSDLDTL |
| 221 | HLQAATPKGYEPDAS |
| 231 | EPDASVTKLAEQYAK |
| 238 | KLAEQYAKENGTKLL |
| 289 | QGYQVTMKTAKVAAS |
| 292 | QVTMKTAKVAASDWT |
| 307 | FLHCLPRKPEEVDDE |
| 331 | FPEAENRKWTIMAVM |
| 46 | GRDLLTLKNFTGEEI |
| 70 | LKFRIKQKGEYLPLL |
| 88 | SLGMIFEKRSTRTRL |
Function
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:2556444, PubMed:6372096, PubMed:8112735). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2556444)
Protein Sequence
10
MLFNLRILLN
20
NAAFRNGHNF
30
MVRNFRCGQP
40
LQNKVQLKGR
50
DLLTLKNFTG
60
EEIKYMLWLS
70
ADLKFRIKQK
80
GEYLPLLQGK
90
SLGMIFEKRS
100
TRTRLSTETG
110
FALLGGHPCF
120
LTTQDIHLGV
130
NESLTDTARV
140
LSSMADAVLA
150
RVYKQSDLDT
160
LAKEASIPII
170
NGLSDLYHPI
180
QILADYLTLQ
190
EHYSSLKGLT
200
LSWIGDGNNI
210
LHSIMMSAAK
220
FGMHLQAATP
230
KGYEPDASVT
240
KLAEQYAKEN
250
GTKLLLTNDP
260
LEAAHGGNVL
270
ITDTWISMGQ
280
EEEKKKRLQA
290
FQGYQVTMKT
300
AKVAASDWTF
310
LHCLPRKPEE
320
VDDEVFYSPR
330
SLVFPEAENR
340
KWTIMAVMVS
350
LLTDYSPQLQ
KPKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004585 | ornithine carbamoyltransferase activity |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Biological Process | GO:0097272 | ammonium homeostasis |
| Biological Process | GO:0019240 | citrulline biosynthetic process |
| Biological Process | GO:0042450 | L-arginine biosynthetic process via ornithine |
| Biological Process | GO:0006593 | L-ornithine catabolic process |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0007494 | midgut development |
| Biological Process | GO:0055081 | monoatomic anion homeostasis |
| Biological Process | GO:0070781 | response to biotin |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0000050 | urea cycle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.