Search Results

Overview

Uniprot ID	P00488
Protein Name	Coagulation factor XIII A chain
Gene Name	F13A1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
258	SGRGNPIKVSRVGSA
447	LIYITAKKDGTHVVE
571	VPKAEFKKETFDVTL
624	RDVLAKQKSTVLTIP
705	PWVSGHRKLIASMSS

Function

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin

Protein Sequence

10 MSETSRTAFG 20 GRRAVPPNNS 30 NAAEDDLPTV 40 ELQGVVPRGV 50 NLQEFLNVTS 60 VHLFKERWDT 70 NKVDHHTDKY 80 ENNKLIVRRG 90 QSFYVQIDFS 100 RPYDPRRDLF 110 RVEYVIGRYP 120 QENKGTYIPV 130 PIVSELQSGK 140 WGAKIVMRED 150 RSVRLSIQSS 160 PKCIVGKFRM 170 YVAVWTPYGV 180 LRTSRNPETD 190 TYILFNPWCE 200 DDAVYLDNEK 210 EREEYVLNDI 220 GVIFYGEVND 230 IKTRSWSYGQ 240 FEDGILDTCL 250 YVMDRAQMDL 260 SGRGNPIKVS 270 RVGSAMVNAK 280 DDEGVLVGSW 290 DNIYAYGVPP 300 SAWTGSVDIL 310 LEYRSSENPV 320 RYGQCWVFAG 330 VFNTFLRCLG 340 IPARIVTNYF 350 SAHDNDANLQ 360 MDIFLEEDGN 370 VNSKLTKDSV 380 WNYHCWNEAW 390 MTRPDLPVGF 400 GGWQAVDSTP 410 QENSDGMYRC 420 GPASVQAIKH 430 GHVCFQFDAP 440 FVFAEVNSDL 450 IYITAKKDGT 460 HVVENVDATH 470 IGKLIVTKQI 480 GGDGMMDITD 490 TYKFQEGQEE 500 ERLALETALM 510 YGAKKPLNTE 520 GVMKSRSNVD 530 MDFEVENAVL 540 GKDFKLSITF 550 RNNSHNRYTI 560 TAYLSANITF 570 YTGVPKAEFK 580 KETFDVTLEP 590 LSFKKEAVLI 600 QAGEYMGQLL 610 EQASLHFFVT 620 ARINETRDVL 630 AKQKSTVLTI 640 PEIIIKVRGT 650 QVVGSDMTVT 660 VEFTNPLKET 670 LRNVWVHLDG 680 PGVTRPMKKM 690 FREIRPNSTV 700 QWEEVCRPWV 710 SGHRKLIASM 720 SSDSLRHVYG 730 ELDVQIQRRP SM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0031093	platelet alpha granule lumen
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity
Biological Process	GO:0007596	blood coagulation
Biological Process	GO:0072378	blood coagulation, fibrin clot formation
Biological Process	GO:0018149	peptide cross-linking

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.