Search Results
Overview
| Uniprot ID | P00491 |
|---|---|
| Protein Name | Purine nucleoside phosphorylase |
| Gene Name | PNP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 265 | EEVLAAGKQAAQKLE |
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:3029074, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964)
Protein Sequence
10
MENGYTYEDY
20
KNTAEWLLSH
30
TKHRPQVAII
40
CGSGLGGLTD
50
KLTQAQIFDY
60
GEIPNFPRST
70
VPGHAGRLVF
80
GFLNGRACVM
90
MQGRFHMYEG
100
YPLWKVTFPV
110
RVFHLLGVDT
120
LVVTNAAGGL
130
NPKFEVGDIM
140
LIRDHINLPG
150
FSGQNPLRGP
160
NDERFGDRFP
170
AMSDAYDRTM
180
RQRALSTWKQ
190
MGEQRELQEG
200
TYVMVAGPSF
210
ETVAECRVLQ
220
KLGADAVGMS
230
TVPEVIVARH
240
CGLRVFGFSL
250
ITNKVIMDYE
260
SLEKANHEEV
270
LAAGKQAAQK
280
LEQFVSILMA
SIPLPDKAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0047975 | guanosine phosphorylase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0001882 | nucleoside binding |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Molecular Function | GO:0002060 | purine nucleobase binding |
| Molecular Function | GO:0004731 | purine-nucleoside phosphorylase activity |
| Biological Process | GO:0000255 | allantoin metabolic process |
| Biological Process | GO:0046059 | dAMP catabolic process |
| Biological Process | GO:0006157 | deoxyadenosine catabolic process |
| Biological Process | GO:0006149 | deoxyinosine catabolic process |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006204 | IMP catabolic process |
| Biological Process | GO:0006148 | inosine catabolic process |
| Biological Process | GO:0006738 | nicotinamide riboside catabolic process |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0009165 | nucleotide biosynthetic process |
| Biological Process | GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
| Biological Process | GO:0043101 | purine-containing compound salvage |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0034418 | urate biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.