Search Results
Overview
| Uniprot ID | P00492 |
|---|---|
| Protein Name | Hypoxanthine-guanine phosphoribosyltransferase |
| Gene Name | HPRT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | TVDFIRLKSYCNDQS |
Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway
Protein Sequence
10
MATRSPGVVI
20
SDDEPGYDLD
30
LFCIPNHYAE
40
DLERVFIPHG
50
LIMDRTERLA
60
RDVMKEMGGH
70
HIVALCVLKG
80
GYKFFADLLD
90
YIKALNRNSD
100
RSIPMTVDFI
110
RLKSYCNDQS
120
TGDIKVIGGD
130
DLSTLTGKNV
140
LIVEDIIDTG
150
KTMQTLLSLV
160
RQYNPKMVKV
170
ASLLVKRTPR
180
SVGYKPDFVG
190
FEIPDKFVVG
200
YALDYNEYFR
210
DLNHVCVISE
TGKAKYKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0052657 | guanine phosphoribosyltransferase activity |
| Molecular Function | GO:0004422 | hypoxanthine phosphoribosyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0046038 | GMP catabolic process |
| Biological Process | GO:0032263 | GMP salvage |
| Biological Process | GO:0006178 | guanine salvage |
| Biological Process | GO:0046100 | hypoxanthine metabolic process |
| Biological Process | GO:0043103 | hypoxanthine salvage |
| Biological Process | GO:0046040 | IMP metabolic process |
| Biological Process | GO:0032264 | IMP salvage |
| Biological Process | GO:0045964 | positive regulation of dopamine metabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0006164 | purine nucleotide biosynthetic process |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.