Overview
| Uniprot ID | P00503 |
|---|
| Protein Name | Aspartate aminotransferase, cytoplasmic |
|---|
| Gene Name | GOT1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 166 |
YRYWDTEKRGLDLQG |
| 33 |
REDPDPRKVNLGVGA |
| 99 |
DSPALQEKRVGGVQS |
Function
Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:4634443). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity)
Protein Sequence
10
MAPPSVFAEV
20
PQAQPVLVFK
30
LIADFREDPD
40
PRKVNLGVGA
50
YRTDDCQPWV
60
LPVVRKVEQR
70
IANDSSLNHE
80
YLPILGLAEF
90
RTCASRLALG
100
DDSPALQEKR
110
VGGVQSLGGT
120
GALRIGAEFL
130
ARWYNGTNNK
140
DTPVYVSSPT
150
WENHNGVFTT
160
AGFKDIRSYR
170
YWDTEKRGLD
180
LQGFLSDLEN
190
APEFSIFVLH
200
ACAHNPTGTD
210
PTPEQWKQIA
220
SVMKRRFLFP
230
FFDSAYQGFA
240
SGNLEKDAWA
250
IRYFVSEGFE
260
LFCAQSFSKN
270
FGLYNERVGN
280
LTVVAKEPDS
290
ILRVLSQMEK
300
IVRVTWSNPP
310
AQGARIVART
320
LSDPELFHEW
330
TGNVKTMADR
340
ILSMRSELRA
350
RLEALKTPGT
360
WNHITDQIGM
370
FSFTGLNPKQ
380
VEYLINEKHI
390
YLLPSGRINM
400
CGLTTKNLDY
410
VATSIHEAVT
KIQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0120554 |
2-aminobutanoate transaminase activity |
| Molecular Function |
GO:0004069 |
L-aspartate:2-oxoglutarate aminotransferase activity |
| Molecular Function |
GO:0047801 |
L-cysteine transaminase activity |
| Molecular Function |
GO:0004609 |
phosphatidylserine decarboxylase activity |
| Molecular Function |
GO:0030170 |
pyridoxal phosphate binding |
| Biological Process |
GO:0006103 |
2-oxoglutarate metabolic process |
| Biological Process |
GO:0006531 |
aspartate metabolic process |
| Biological Process |
GO:0032869 |
cellular response to insulin stimulus |
| Biological Process |
GO:0006094 |
gluconeogenesis |
| Biological Process |
GO:0006536 |
glutamate metabolic process |
| Biological Process |
GO:0006114 |
glycerol biosynthetic process |
| Biological Process |
GO:0006532 |
L-aspartate biosynthetic process |
| Biological Process |
GO:0006533 |
L-aspartate catabolic process |
| Biological Process |
GO:0043490 |
malate-aspartate shuttle |
| Biological Process |
GO:0051384 |
response to glucocorticoid |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.