Search Results
Overview
| Uniprot ID | P00506 |
|---|---|
| Protein Name | Aspartate aminotransferase, mitochondrial |
| Gene Name | GOT2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | GENNEVLKSGRYVTV |
| 234 | KEMATLVKKNNLFAF |
| 296 | GAFTVVCKDAEEAKR |
| 309 | KRVESQLKILIRPMY |
| 363 | TQLVSNLKKEGSSHN |
| 82 | YVLPSVRKAEAQIAA |
| 90 | AEAQIAAKNLDKEYL |
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids
Protein Sequence
10
MALLHSGRVL
20
SGVASAFHPG
30
LAAAASARAS
40
SWWAHVEMGP
50
PDPILGVTEA
60
FKRDTNSKKM
70
NLGVGAYRDD
80
NGKPYVLPSV
90
RKAEAQIAAK
100
NLDKEYLPIG
110
GLAEFCKASA
120
ELALGENNEV
130
LKSGRYVTVQ
140
TISGTGALRI
150
GANFLQRFFK
160
FSRDVFLPKP
170
SWGNHTPIFR
180
DAGMQLHSYR
190
YYDPKTCGFD
200
FTGALEDISK
210
IPAQSVILLH
220
ACAHNPTGVD
230
PRPEQWKEMA
240
TLVKKNNLFA
250
FFDMAYQGFA
260
SGDGNKDAWA
270
VRHFIEQGIN
280
VCLCQSYAKN
290
MGLYGERVGA
300
FTVVCKDAEE
310
AKRVESQLKI
320
LIRPMYSNPP
330
VNGARIASTI
340
LTSPDLRQQW
350
LQEVKGMADR
360
IISMRTQLVS
370
NLKKEGSSHN
380
WQHIVDQIGM
390
FCFTGIKPEQ
400
VERLTKEFSI
410
YMTKDGRISV
420
AGVTSGNVGY
430
LAHAIHQVTK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0016212 | kynurenine-oxoglutarate transaminase activity |
| Molecular Function | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
| Biological Process | GO:0006531 | aspartate metabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0006533 | L-aspartate catabolic process |
| Biological Process | GO:0006869 | lipid transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.