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Overview

Uniprot IDP00507
Protein NameAspartate aminotransferase, mitochondrial
Gene NameGot2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
122 GENSEVLKSGRFVTV
234 KEMAAVVKKKNLFAF
279 CLCQSYAKNMGLYGE
296 GAFTVVCKDAEEAKR
309 KRVESQLKILIRPLY
338 LTSPDLRKQWLQEVK
345 KQWLQEVKGMADRII
363 TQLVSNLKKEGSSHN
396 EQVERLTKEFSVYMT
404 EFSVYMTKDGRISVA
59 KRDTNSKKMNLGVGA
73 AYRDDNGKPYVLPSV
82 YVLPSVRKAEAQIAG
90 AEAQIAGKNLDKEYL

Function

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids (By similarity)

Protein Sequence

10 MALLHSGRVL 20 SGMAAAFHPG 30 LAAAASARAS 40 SWWTHVEMGP 50 PDPILGVTEA 60 FKRDTNSKKM 70 NLGVGAYRDD 80 NGKPYVLPSV 90 RKAEAQIAGK 100 NLDKEYLPIG 110 GLADFCKASA 120 ELALGENSEV 130 LKSGRFVTVQ 140 TISGTGALRV 150 GASFLQRFFK 160 FSRDVFLPKP 170 SWGNHTPIFR 180 DAGMQLQGYR 190 YYDPKTCGFD 200 FSGALEDISK 210 IPEQSVLLLH 220 ACAHNPTGVD 230 PRPEQWKEMA 240 AVVKKKNLFA 250 FFDMAYQGFA 260 SGDGDKDAWA 270 VRHFIEQGIN 280 VCLCQSYAKN 290 MGLYGERVGA 300 FTVVCKDAEE 310 AKRVESQLKI 320 LIRPLYSNPP 330 LNGARIAATI 340 LTSPDLRKQW 350 LQEVKGMADR 360 IISMRTQLVS 370 NLKKEGSSHN 380 WQHITDQIGM 390 FCFTGLKPEQ 400 VERLTKEFSV 410 YMTKDGRISV 420 AGVTSGNVGY 430 LAHAIHQVTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030315 T-tubule
Molecular Function GO:0016597 amino acid binding
Molecular Function GO:0031406 carboxylic acid binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0016212 kynurenine-oxoglutarate transaminase activity
Molecular Function GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006520 amino acid metabolic process
Biological Process GO:0006531 aspartate metabolic process
Biological Process GO:0043648 dicarboxylic acid metabolic process
Biological Process GO:0015908 fatty acid transport
Biological Process GO:0007565 female pregnancy
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0006532 L-aspartate biosynthetic process
Biological Process GO:0006533 L-aspartate catabolic process
Biological Process GO:0097054 L-glutamate biosynthetic process
Biological Process GO:0006538 L-glutamate catabolic process
Biological Process GO:0019550 L-glutamate catabolic process to aspartate
Biological Process GO:0007595 lactation
Biological Process GO:0043490 malate-aspartate shuttle
Biological Process GO:0006107 oxaloacetate metabolic process
Biological Process GO:0045471 response to ethanol
Biological Process GO:0032868 response to insulin
Biological Process GO:0014850 response to muscle activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.