Search Results

Overview

Uniprot IDP00533
Protein NameEpidermal growth factor receptor
Gene NameEGFR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
713 ILKETEFKKIKVLGS
739 IPEGEKVKIPVAIKE
745 VKIPVAIKELREATS

Function

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity)

Protein Sequence

10 MRPSGTAGAA 20 LLALLAALCP 30 ASRALEEKKV 40 CQGTSNKLTQ 50 LGTFEDHFLS 60 LQRMFNNCEV 70 VLGNLEITYV 80 QRNYDLSFLK 90 TIQEVAGYVL 100 IALNTVERIP 110 LENLQIIRGN 120 MYYENSYALA 130 VLSNYDANKT 140 GLKELPMRNL 150 QEILHGAVRF 160 SNNPALCNVE 170 SIQWRDIVSS 180 DFLSNMSMDF 190 QNHLGSCQKC 200 DPSCPNGSCW 210 GAGEENCQKL 220 TKIICAQQCS 230 GRCRGKSPSD 240 CCHNQCAAGC 250 TGPRESDCLV 260 CRKFRDEATC 270 KDTCPPLMLY 280 NPTTYQMDVN 290 PEGKYSFGAT 300 CVKKCPRNYV 310 VTDHGSCVRA 320 CGADSYEMEE 330 DGVRKCKKCE 340 GPCRKVCNGI 350 GIGEFKDSLS 360 INATNIKHFK 370 NCTSISGDLH 380 ILPVAFRGDS 390 FTHTPPLDPQ 400 ELDILKTVKE 410 ITGFLLIQAW 420 PENRTDLHAF 430 ENLEIIRGRT 440 KQHGQFSLAV 450 VSLNITSLGL 460 RSLKEISDGD 470 VIISGNKNLC 480 YANTINWKKL 490 FGTSGQKTKI 500 ISNRGENSCK 510 ATGQVCHALC 520 SPEGCWGPEP 530 RDCVSCRNVS 540 RGRECVDKCN 550 LLEGEPREFV 560 ENSECIQCHP 570 ECLPQAMNIT 580 CTGRGPDNCI 590 QCAHYIDGPH 600 CVKTCPAGVM 610 GENNTLVWKY 620 ADAGHVCHLC 630 HPNCTYGCTG 640 PGLEGCPTNG 650 PKIPSIATGM 660 VGALLLLLVV 670 ALGIGLFMRR 680 RHIVRKRTLR 690 RLLQERELVE 700 PLTPSGEAPN 710 QALLRILKET 720 EFKKIKVLGS 730 GAFGTVYKGL 740 WIPEGEKVKI 750 PVAIKELREA 760 TSPKANKEIL 770 DEAYVMASVD 780 NPHVCRLLGI 790 CLTSTVQLIT 800 QLMPFGCLLD 810 YVREHKDNIG 820 SQYLLNWCVQ 830 IAKGMNYLED 840 RRLVHRDLAA 850 RNVLVKTPQH 860 VKITDFGLAK 870 LLGAEEKEYH 880 AEGGKVPIKW 890 MALESILHRI 900 YTHQSDVWSY 910 GVTVWELMTF 920 GSKPYDGIPA 930 SEISSILEKG 940 ERLPQPPICT 950 IDVYMIMVKC 960 WMIDADSRPK 970 FRELIIEFSK 980 MARDPQRYLV 990 IQGDERMHLP 1000 SPTDSNFYRA 1010 LMDEEDMDDV 1020 VDADEYLIPQ 1030 QGFFSSPSTS 1040 RTPLLSSLSA 1050 TSNNSTVACI 1060 DRNGLQSCPI 1070 KEDSFLQRYS 1080 SDPTGALTED 1090 SIDDTFLPVP 1100 EYINQSVPKR 1110 PAGSVQNPVY 1120 HNQPLNPAPS 1130 RDPHYQDPHS 1140 TAVGNPEYLN 1150 TVQPTCVNST 1160 FDSPAHWAQK 1170 GSHQISLDNP 1180 DYQQDFFPKE 1190 AKPNGIFKGS 1200 TAENAEYLRV 1210 APQSSEFIGA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0097708 intracellular vesicle
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0097489 multivesicular body, internal vesicle lumen
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0032587 ruffle membrane
Cellular Component GO:0070435 Shc-EGFR complex
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0048408 epidermal growth factor binding
Molecular Function GO:0005006 epidermal growth factor receptor activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0004709 MAP kinase kinase kinase activity
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0030296 protein tyrosine kinase activator activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Molecular Function GO:0004714 transmembrane receptor protein tyrosine kinase activity
Molecular Function GO:0004888 transmembrane signaling receptor activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Molecular Function GO:0001618 virus receptor activity
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038134 ERBB2-EGFR signaling pathway
Biological Process GO:0007611 learning or memory
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1905208 negative regulation of cardiocyte differentiation
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0001503 ossification
Biological Process GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0045740 positive regulation of DNA replication
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:1902895 positive regulation of miRNA transcription
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0090037 positive regulation of protein kinase C signaling
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051205 protein insertion into membrane
Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0070141 response to UV-A
Biological Process GO:0007165 signal transduction
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.