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Overview

Uniprot IDP00568
Protein NameAdenylate kinase isoenzyme 1
Gene NameAK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
166 PVIAFYEKRGIVRKV
21 VGGPGSGKGTQCEKI
27 GKGTQCEKIVQKYGY
31 QCEKIVQKYGYTHLS
56 SGSARGKKLSEIMEK
88 VAKVNTSKGFLIDGY

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) (PubMed:21080915, PubMed:23416111, PubMed:2542324). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)

Protein Sequence

10 MEEKLKKTKI 20 IFVVGGPGSG 30 KGTQCEKIVQ 40 KYGYTHLSTG 50 DLLRSEVSSG 60 SARGKKLSEI 70 MEKGQLVPLE 80 TVLDMLRDAM 90 VAKVNTSKGF 100 LIDGYPREVQ 110 QGEEFERRIG 120 QPTLLLYVDA 130 GPETMTQRLL 140 KRGETSGRVD 150 DNEETIKKRL 160 ETYYKATEPV 170 IAFYEKRGIV 180 RKVNAEGSVD 190 SVFSQVCTHL DALK

Gene Ontology

Classification GO ID Description
Biological Process GO:0015949 nucleobase-containing small molecule interconversion
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0001520 outer dense fiber
Molecular Function GO:0004017 AMP kinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0047506 dAMP kinase activity
Molecular Function GO:0004550 nucleoside diphosphate kinase activity
Biological Process GO:0006172 ADP biosynthetic process
Biological Process GO:0046033 AMP metabolic process
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0009142 nucleoside triphosphate biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.