Search Results
Overview
| Uniprot ID | P00734 |
|---|---|
| Protein Name | Prothrombin |
| Gene Name | F2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 247 | AQAKALSKHQDFNSA |
| 498 | SLLQAGYKGRVTGWG |
| 537 | IVERPVCKDSTRIRI |
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
Protein Sequence
10
MAHVRGLQLP
20
GCLALAALCS
30
LVHSQHVFLA
40
PQQARSLLQR
50
VRRANTFLEE
60
VRKGNLEREC
70
VEETCSYEEA
80
FEALESSTAT
90
DVFWAKYTAC
100
ETARTPRDKL
110
AACLEGNCAE
120
GLGTNYRGHV
130
NITRSGIECQ
140
LWRSRYPHKP
150
EINSTTHPGA
160
DLQENFCRNP
170
DSSTTGPWCY
180
TTDPTVRRQE
190
CSIPVCGQDQ
200
VTVAMTPRSE
210
GSSVNLSPPL
220
EQCVPDRGQQ
230
YQGRLAVTTH
240
GLPCLAWASA
250
QAKALSKHQD
260
FNSAVQLVEN
270
FCRNPDGDEE
280
GVWCYVAGKP
290
GDFGYCDLNY
300
CEEAVEEETG
310
DGLDEDSDRA
320
IEGRTATSEY
330
QTFFNPRTFG
340
SGEADCGLRP
350
LFEKKSLEDK
360
TERELLESYI
370
DGRIVEGSDA
380
EIGMSPWQVM
390
LFRKSPQELL
400
CGASLISDRW
410
VLTAAHCLLY
420
PPWDKNFTEN
430
DLLVRIGKHS
440
RTRYERNIEK
450
ISMLEKIYIH
460
PRYNWRENLD
470
RDIALMKLKK
480
PVAFSDYIHP
490
VCLPDRETAA
500
SLLQAGYKGR
510
VTGWGNLKET
520
WTANVGKGQP
530
SVLQVVNLPI
540
VERPVCKDST
550
RIRITDNMFC
560
AGYKPDEGKR
570
GDACEGDSGG
580
PFVMKSPFNN
590
RWYQMGIVSW
600
GEGCDRDGKY
610
GFYTHVFRLK
620
KWIQKVIDQF
GE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005796 | Golgi lumen |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0001530 | lipopolysaccharide binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0070053 | thrombospondin receptor activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0051838 | cytolysis by host of symbiont cells |
| Biological Process | GO:0042730 | fibrinolysis |
| Biological Process | GO:0048712 | negative regulation of astrocyte differentiation |
| Biological Process | GO:0030195 | negative regulation of blood coagulation |
| Biological Process | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:0051918 | negative regulation of fibrinolysis |
| Biological Process | GO:0010544 | negative regulation of platelet activation |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0070945 | neutrophil-mediated killing of gram-negative bacterium |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0030194 | positive regulation of blood coagulation |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:1900738 | positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0030193 | regulation of blood coagulation |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0070493 | thrombin-activated receptor signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.