Search Results

Overview

Uniprot IDP00738
Protein NameHaptoglobin
Gene NameHP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 VYTLNNEKQWINKAV
141 INKAVGDKLPECEAV
151 ECEAVCGKPKNPANP
153 EAVCGKPKNPANPVQ
170 LGGHLDAKGSFPWQA
227 TLTLYVGKKQLVEIE
228 LTLYVGKKQLVEIEK
255 GLIKLKQKVSVNERV
270 MPICLPSKDYAEVGR
291 WGRNANFKFTDHLKY
297 FKFTDHLKYVMLPVA
321 EGSTVPEKKTPKSPV
325 VPEKKTPKSPVGVQP
345 TFCAGMSKYQEDTCY
53 HSVRYQCKNYYKLRT
71 GVYTLNDKKQWINKA
77 DKKQWINKAVGDKLP
94 EADDGCPKPPEIAHG

Function

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway

Protein Sequence

10 MSALGAVIAL 20 LLWGQLFAVD 30 SGNDVTDIAD 40 DGCPKPPEIA 50 HGYVEHSVRY 60 QCKNYYKLRT 70 EGDGVYTLND 80 KKQWINKAVG 90 DKLPECEADD 100 GCPKPPEIAH 110 GYVEHSVRYQ 120 CKNYYKLRTE 130 GDGVYTLNNE 140 KQWINKAVGD 150 KLPECEAVCG 160 KPKNPANPVQ 170 RILGGHLDAK 180 GSFPWQAKMV 190 SHHNLTTGAT 200 LINEQWLLTT 210 AKNLFLNHSE 220 NATAKDIAPT 230 LTLYVGKKQL 240 VEIEKVVLHP 250 NYSQVDIGLI 260 KLKQKVSVNE 270 RVMPICLPSK 280 DYAEVGRVGY 290 VSGWGRNANF 300 KFTDHLKYVM 310 LPVADQDQCI 320 RHYEGSTVPE 330 KKTPKSPVGV 340 QPILNEHTFC 350 AGMSKYQEDT 360 CYGDAGSAFA 370 VHDLEEDTWY 380 ATGILSFDKS 390 CAVAEYGVYV 400 KVTSIQDWVQ KTIAEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0071682 endocytic vesicle lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0031838 haptoglobin-hemoglobin complex
Cellular Component GO:0035580 specific granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0016209 antioxidant activity
Molecular Function GO:0030492 hemoglobin binding
Molecular Function GO:0004252 serine-type endopeptidase activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0006952 defense response
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0002376 immune system process
Biological Process GO:0006954 inflammatory response
Biological Process GO:2000296 negative regulation of hydrogen peroxide catabolic process
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0031638 zymogen activation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.