Search Results

Overview

Uniprot IDP00751
Protein NameComplement factor B
Gene NameCFB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
291 SNFTGAKKCLVNLIE
306 KVASYGVKPRYGLVT
348 EINYEDHKLKSGTNT
446 INALASKKDNEQHVF
454 DNEQHVFKVKDMENL
587 IKLKNKLKYGQTIRP
668 QYAPGYDKVKDISEV
707 GGPLIVHKRSRFIQV
86 TGSWSTLKTQDQKTV

Function

Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases (PubMed:3638964, PubMed:624565, PubMed:6554279, PubMed:6919543, PubMed:9748277). CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases (PubMed:6769474, PubMed:9748277)

Protein Sequence

10 MGSNLSPQLC 20 LMPFILGLLS 30 GGVTTTPWSL 40 ARPQGSCSLE 50 GVEIKGGSFR 60 LLQEGQALEY 70 VCPSGFYPYP 80 VQTRTCRSTG 90 SWSTLKTQDQ 100 KTVRKAECRA 110 IHCPRPHDFE 120 NGEYWPRSPY 130 YNVSDEISFH 140 CYDGYTLRGS 150 ANRTCQVNGR 160 WSGQTAICDN 170 GAGYCSNPGI 180 PIGTRKVGSQ 190 YRLEDSVTYH 200 CSRGLTLRGS 210 QRRTCQEGGS 220 WSGTEPSCQD 230 SFMYDTPQEV 240 AEAFLSSLTE 250 TIEGVDAEDG 260 HGPGEQQKRK 270 IVLDPSGSMN 280 IYLVLDGSDS 290 IGASNFTGAK 300 KCLVNLIEKV 310 ASYGVKPRYG 320 LVTYATYPKI 330 WVKVSEADSS 340 NADWVTKQLN 350 EINYEDHKLK 360 SGTNTKKALQ 370 AVYSMMSWPD 380 DVPPEGWNRT 390 RHVIILMTDG 400 LHNMGGDPIT 410 VIDEIRDLLY 420 IGKDRKNPRE 430 DYLDVYVFGV 440 GPLVNQVNIN 450 ALASKKDNEQ 460 HVFKVKDMEN 470 LEDVFYQMID 480 ESQSLSLCGM 490 VWEHRKGTDY 500 HKQPWQAKIS 510 VIRPSKGHES 520 CMGAVVSEYF 530 VLTAAHCFTV 540 DDKEHSIKVS 550 VGGEKRDLEI 560 EVVLFHPNYN 570 INGKKEAGIP 580 EFYDYDVALI 590 KLKNKLKYGQ 600 TIRPICLPCT 610 EGTTRALRLP 620 PTTTCQQQKE 630 ELLPAQDIKA 640 LFVSEEEKKL 650 TRKEVYIKNG 660 DKKGSCERDA 670 QYAPGYDKVK 680 DISEVVTPRF 690 LCTGGVSPYA 700 DPNTCRGDSG 710 GPLIVHKRSR 720 FIQVGVISWG 730 VVDVCKNQKR 740 QKQVPAHARD 750 FHINLFQVLP 760 WLKEKLQDED LGFL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0009986 cell surface
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0106139 symbiont cell surface
Molecular Function GO:0001848 complement binding
Molecular Function GO:0004252 serine-type endopeptidase activity
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006508 proteolysis
Biological Process GO:0009617 response to bacterium

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.