Search Results

Overview

Uniprot IDP00915
Protein NameCarbonic anhydrase 1
Gene NameCA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 VAHWNSAKYSSLAEA
157 KVGEANPKLQKVLDA
160 EANPKLQKVLDALQA
169 LDALQAIKTKGKRAP
40 DIKTSETKHDTSLKP
46 TKHDTSLKPISVSYN
81 NDNRSVLKGGPFSDS

Function

Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:18618712, PubMed:19186056, PubMed:19206230). Can hydrate cyanamide to urea (PubMed:10550681)

Protein Sequence

10 MASPDWGYDD 20 KNGPEQWSKL 30 YPIANGNNQS 40 PVDIKTSETK 50 HDTSLKPISV 60 SYNPATAKEI 70 INVGHSFHVN 80 FEDNDNRSVL 90 KGGPFSDSYR 100 LFQFHFHWGS 110 TNEHGSEHTV 120 DGVKYSAELH 130 VAHWNSAKYS 140 SLAEAASKAD 150 GLAVIGVLMK 160 VGEANPKLQK 170 VLDALQAIKT 180 KGKRAPFTNF 190 DPSTLLPSSL 200 DFWTYPGSLT 210 HPPLYESVTW 220 IICKESISVS 230 SEQLAQFRSL 240 LSNVEGDNAV 250 PMQHNNRPTQ 260 PLKGRTVRAS F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0004064 arylesterase activity
Molecular Function GO:0004089 carbonate dehydratase activity
Molecular Function GO:0018820 cyanamide hydratase activity
Molecular Function GO:0016836 hydro-lyase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0009750 response to fructose

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.