Search Results

Overview

Uniprot IDP00918
Protein NameCarbonic anhydrase 2
Gene NameCA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
111 GSEHTVDKKKYAAEL
113 EHTVDKKKYAAELHL
126 HLVHWNTKYGDFGKA
153 FLKVGSAKPGLQKVV
158 SAKPGLQKVVDVLDS
167 VDVLDSIKTKGKSAD
171 DSIKTKGKSADFTNF
18 NGPEHWHKDFPIAKG
212 CVTWIVLKEPISVSS
224 VSSEQVLKFRKLNFN
24 HKDFPIAKGERQSPV
251 WRPAQPLKNRQIKAS
256 PLKNRQIKASFK***
39 DIDTHTAKYDPSLKP
45 AKYDPSLKPLSVSYD
80 SQDKAVLKGGPLDGT
9 SHHWGYGKHNGPEHW

Function

Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption

Protein Sequence

10 MSHHWGYGKH 20 NGPEHWHKDF 30 PIAKGERQSP 40 VDIDTHTAKY 50 DPSLKPLSVS 60 YDQATSLRIL 70 NNGHAFNVEF 80 DDSQDKAVLK 90 GGPLDGTYRL 100 IQFHFHWGSL 110 DGQGSEHTVD 120 KKKYAAELHL 130 VHWNTKYGDF 140 GKAVQQPDGL 150 AVLGIFLKVG 160 SAKPGLQKVV 170 DVLDSIKTKG 180 KSADFTNFDP 190 RGLLPESLDY 200 WTYPGSLTTP 210 PLLECVTWIV 220 LKEPISVSSE 230 QVLKFRKLNF 240 NGEGEPEELM 250 VDNWRPAQPL 260 KNRQIKASFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004064 arylesterase activity
Molecular Function GO:0004089 carbonate dehydratase activity
Molecular Function GO:0018820 cyanamide hydratase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0038166 angiotensin-activated signaling pathway
Biological Process GO:0015670 carbon dioxide transport
Biological Process GO:2001150 positive regulation of dipeptide transmembrane transport
Biological Process GO:0051453 regulation of intracellular pH
Biological Process GO:0044070 regulation of monoatomic anion transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.