Search Results
Overview
| Uniprot ID | P01008 |
|---|---|
| Protein Name | Antithrombin-III |
| Gene Name | SERPINC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | KLQPLDFKENAEQSR |
| 260 | FKGLWKSKFSPENTR |
| 268 | FSPENTRKELFYKAD |
| 273 | TRKELFYKADGESCS |
| 382 | LFSPEKSKLPGIVAE |
Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin
Protein Sequence
10
MYSNVIGTVT
20
SGKRKVYLLS
30
LLLIGFWDCV
40
TCHGSPVDIC
50
TAKPRDIPMN
60
PMCIYRSPEK
70
KATEDEGSEQ
80
KIPEATNRRV
90
WELSKANSRF
100
ATTFYQHLAD
110
SKNDNDNIFL
120
SPLSISTAFA
130
MTKLGACNDT
140
LQQLMEVFKF
150
DTISEKTSDQ
160
IHFFFAKLNC
170
RLYRKANKSS
180
KLVSANRLFG
190
DKSLTFNETY
200
QDISELVYGA
210
KLQPLDFKEN
220
AEQSRAAINK
230
WVSNKTEGRI
240
TDVIPSEAIN
250
ELTVLVLVNT
260
IYFKGLWKSK
270
FSPENTRKEL
280
FYKADGESCS
290
ASMMYQEGKF
300
RYRRVAEGTQ
310
VLELPFKGDD
320
ITMVLILPKP
330
EKSLAKVEKE
340
LTPEVLQEWL
350
DELEEMMLVV
360
HMPRFRIEDG
370
FSLKEQLQDM
380
GLVDLFSPEK
390
SKLPGIVAEG
400
RDDLYVSDAF
410
HKAFLEVNEE
420
GSEAAASTAV
430
VIAGRSLNPN
440
RVTFKANRPF
450
LVFIREVPLN
460
TIIFMGRVAN
PCVK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0030193 | regulation of blood coagulation |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.