Search Results
Overview
| Uniprot ID | P01011 |
|---|---|
| Protein Name | Alpha-1-antichymotrypsin |
| Gene Name | SERPINA3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 158 | DRFTEDAKRLYGSEA |
| 177 | FQDSAAAKKLINDYV |
| 178 | QDSAAAKKLINDYVK |
| 216 | NYIFFKAKWEMPFDP |
| 315 | IGELYLPKFSISRDY |
Function
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2
Protein Sequence
10
MERMLPLLAL
20
GLLAAGFCPA
30
VLCHPNSPLD
40
EENLTQENQD
50
RGTHVDLGLA
60
SANVDFAFSL
70
YKQLVLKAPD
80
KNVIFSPLSI
90
STALAFLSLG
100
AHNTTLTEIL
110
KGLKFNLTET
120
SEAEIHQSFQ
130
HLLRTLNQSS
140
DELQLSMGNA
150
MFVKEQLSLL
160
DRFTEDAKRL
170
YGSEAFATDF
180
QDSAAAKKLI
190
NDYVKNGTRG
200
KITDLIKDLD
210
SQTMMVLVNY
220
IFFKAKWEMP
230
FDPQDTHQSR
240
FYLSKKKWVM
250
VPMMSLHHLT
260
IPYFRDEELS
270
CTVVELKYTG
280
NASALFILPD
290
QDKMEEVEAM
300
LLPETLKRWR
310
DSLEFREIGE
320
LYLPKFSISR
330
DYNLNDILLQ
340
LGIEEAFTSK
350
ADLSGITGAR
360
NLAVSQVVHK
370
AVLDVFEEGT
380
EASAATAVKI
390
TLLSALVETR
400
TIVRFNRPFL
410
MIIVPTDTQN
420
IFFMSKVTNP
KQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0030277 | maintenance of gastrointestinal epithelium |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:0034097 | response to cytokine |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.