Search Results

Overview

Uniprot IDP01024
Protein NameComplement C3
Gene NameC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 KSEKGRNKFVTVQAT
1050 QGALELIKKGYTQQL
1155 LISLQEAKDICEEQV
1203 LAQMGRLKGPLLNKF
1209 LKGPLLNKFLTTAKD
1215 NKFLTTAKDKNRWED
1353 TMYHAKAKDQLTCNK
1364 TCNKFDLKVTIKPAP
1368 FDLKVTIKPAPETEK
1431 GVDRYISKYELDKAF
155 RIFTVNHKLLPVGRT
305 GEVVLSRKVLLDGVQ
359 PYQIHFTKTPKYFKP
418 INTHPSQKPLSITVR
428 SITVRTKKQELSEAE
486 MDRAHEAKIRYYTYL
497 YTYLIMNKGRLLKAG
556 DSVWVDVKDSCVGSL
566 CVGSLVVKSGQSEDR
584 PGQQMTLKIEGDHGA
615 KNKLTQSKIWDVVEK
622 KIWDVVEKADIGCTP
633 GCTPGSGKDYAGVFS
66 VHDFPGKKLVLSSEK
678 RSVQLTEKRMDKVGK
722 SLGEACKKVFLDCCN
861 YRQNQELKVRVELLH
879 FCSLATTKRRHQQTV

Function

Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system

Protein Sequence

10 MGPTSGPSLL 20 LLLLTHLPLA 30 LGSPMYSIIT 40 PNILRLESEE 50 TMVLEAHDAQ 60 GDVPVTVTVH 70 DFPGKKLVLS 80 SEKTVLTPAT 90 NHMGNVTFTI 100 PANREFKSEK 110 GRNKFVTVQA 120 TFGTQVVEKV 130 VLVSLQSGYL 140 FIQTDKTIYT 150 PGSTVLYRIF 160 TVNHKLLPVG 170 RTVMVNIENP 180 EGIPVKQDSL 190 SSQNQLGVLP 200 LSWDIPELVN 210 MGQWKIRAYY 220 ENSPQQVFST 230 EFEVKEYVLP 240 SFEVIVEPTE 250 KFYYIYNEKG 260 LEVTITARFL 270 YGKKVEGTAF 280 VIFGIQDGEQ 290 RISLPESLKR 300 IPIEDGSGEV 310 VLSRKVLLDG 320 VQNPRAEDLV 330 GKSLYVSATV 340 ILHSGSDMVQ 350 AERSGIPIVT 360 SPYQIHFTKT 370 PKYFKPGMPF 380 DLMVFVTNPD 390 GSPAYRVPVA 400 VQGEDTVQSL 410 TQGDGVAKLS 420 INTHPSQKPL 430 SITVRTKKQE 440 LSEAEQATRT 450 MQALPYSTVG 460 NSNNYLHLSV 470 LRTELRPGET 480 LNVNFLLRMD 490 RAHEAKIRYY 500 TYLIMNKGRL 510 LKAGRQVREP 520 GQDLVVLPLS 530 ITTDFIPSFR 540 LVAYYTLIGA 550 SGQREVVADS 560 VWVDVKDSCV 570 GSLVVKSGQS 580 EDRQPVPGQQ 590 MTLKIEGDHG 600 ARVVLVAVDK 610 GVFVLNKKNK 620 LTQSKIWDVV 630 EKADIGCTPG 640 SGKDYAGVFS 650 DAGLTFTSSS 660 GQQTAQRAEL 670 QCPQPAARRR 680 RSVQLTEKRM 690 DKVGKYPKEL 700 RKCCEDGMRE 710 NPMRFSCQRR 720 TRFISLGEAC 730 KKVFLDCCNY 740 ITELRRQHAR 750 ASHLGLARSN 760 LDEDIIAEEN 770 IVSRSEFPES 780 WLWNVEDLKE 790 PPKNGISTKL 800 MNIFLKDSIT 810 TWEILAVSMS 820 DKKGICVADP 830 FEVTVMQDFF 840 IDLRLPYSVV 850 RNEQVEIRAV 860 LYNYRQNQEL 870 KVRVELLHNP 880 AFCSLATTKR 890 RHQQTVTIPP 900 KSSLSVPYVI 910 VPLKTGLQEV 920 EVKAAVYHHF 930 ISDGVRKSLK 940 VVPEGIRMNK 950 TVAVRTLDPE 960 RLGREGVQKE 970 DIPPADLSDQ 980 VPDTESETRI 990 LLQGTPVAQM 1000 TEDAVDAERL 1010 KHLIVTPSGC 1020 GEQNMIGMTP 1030 TVIAVHYLDE 1040 TEQWEKFGLE 1050 KRQGALELIK 1060 KGYTQQLAFR 1070 QPSSAFAAFV 1080 KRAPSTWLTA 1090 YVVKVFSLAV 1100 NLIAIDSQVL 1110 CGAVKWLILE 1120 KQKPDGVFQE 1130 DAPVIHQEMI 1140 GGLRNNNEKD 1150 MALTAFVLIS 1160 LQEAKDICEE 1170 QVNSLPGSIT 1180 KAGDFLEANY 1190 MNLQRSYTVA 1200 IAGYALAQMG 1210 RLKGPLLNKF 1220 LTTAKDKNRW 1230 EDPGKQLYNV 1240 EATSYALLAL 1250 LQLKDFDFVP 1260 PVVRWLNEQR 1270 YYGGGYGSTQ 1280 ATFMVFQALA 1290 QYQKDAPDHQ 1300 ELNLDVSLQL 1310 PSRSSKITHR 1320 IHWESASLLR 1330 SEETKENEGF 1340 TVTAEGKGQG 1350 TLSVVTMYHA 1360 KAKDQLTCNK 1370 FDLKVTIKPA 1380 PETEKRPQDA 1390 KNTMILEICT 1400 RYRGDQDATM 1410 SILDISMMTG 1420 FAPDTDDLKQ 1430 LANGVDRYIS 1440 KYELDKAFSD 1450 RNTLIIYLDK 1460 VSHSEDDCLA 1470 FKVHQYFNVE 1480 LIQPGAVKVY 1490 AYYNLEESCT 1500 RFYHPEKEDG 1510 KLNKLCRDEL 1520 CRCAEENCFI 1530 QKSDDKVTLE 1540 ERLDKACEPG 1550 VDYVYKTRLV 1560 KVQLSNDFDE 1570 YIMAIEQTIK 1580 SGSDEVQVGQ 1590 QRTFISPIKC 1600 REALKLEEKK 1610 HYLMWGLSSD 1620 FWGEKPNLSY 1630 IIGKDTWVEH 1640 WPEEDECQDE 1650 ENQKQCQDLG 1660 AFTESMVVFG CPN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding
Molecular Function GO:0004866 endopeptidase inhibitor activity
Molecular Function GO:0048018 receptor ligand activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0042113 B cell activation
Biological Process GO:0006956 complement activation
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0160257 complement activation, GZMK pathway
Biological Process GO:0002430 complement receptor mediated signaling pathway
Biological Process GO:0150062 complement-mediated synapse pruning
Biological Process GO:0006631 fatty acid metabolic process
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0016322 neuron remodeling
Biological Process GO:0001970 positive regulation of activation of membrane attack complex
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:2000427 positive regulation of apoptotic cell clearance
Biological Process GO:0010828 positive regulation of D-glucose transmembrane transport
Biological Process GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0010884 positive regulation of lipid storage
Biological Process GO:0060100 positive regulation of phagocytosis, engulfment
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0010575 positive regulation of vascular endothelial growth factor production
Biological Process GO:0010866 regulation of triglyceride biosynthetic process
Biological Process GO:0007165 signal transduction
Biological Process GO:0150064 vertebrate eye-specific patterning

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.