Overview
| Uniprot ID | P01033 |
|---|
| Protein Name | Metalloproteinase inhibitor 1 |
|---|
| Gene Name | TIMP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 70 |
IKMTKMYKGFQALGD |
Function
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors
Protein Sequence
10
MAPFEPLASG
20
ILLLLWLIAP
30
SRACTCVPPH
40
PQTAFCNSDL
50
VIRAKFVGTP
60
EVNQTTLYQR
70
YEIKMTKMYK
80
GFQALGDAAD
90
IRFVYTPAME
100
SVCGYFHRSH
110
NRSEEFLIAG
120
KLQDGLLHIT
130
TCSFVAPWNS
140
LSLAQRRGFT
150
KTYTVGCEEC
160
TVFPCLSIPC
170
KLQSGTHCLW
180
TDQLLQGSEK
190
GFQSRHLACL
200
PREPGLCTWQ
SLRSQIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005604 |
basement membrane |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0031093 |
platelet alpha granule lumen |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0008083 |
growth factor activity |
| Molecular Function |
GO:0008191 |
metalloendopeptidase inhibitor activity |
| Molecular Function |
GO:0030414 |
peptidase inhibitor activity |
| Molecular Function |
GO:0002020 |
protease binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0051216 |
cartilage development |
| Biological Process |
GO:1905641 |
cellular response to acetaldehyde |
| Biological Process |
GO:1901653 |
cellular response to peptide |
| Biological Process |
GO:0071492 |
cellular response to UV-A |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
| Biological Process |
GO:0043086 |
negative regulation of catalytic activity |
| Biological Process |
GO:0010951 |
negative regulation of endopeptidase activity |
| Biological Process |
GO:0051045 |
negative regulation of membrane protein ectodomain proteolysis |
| Biological Process |
GO:1905049 |
negative regulation of metallopeptidase activity |
| Biological Process |
GO:1901164 |
negative regulation of trophoblast cell migration |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:2001044 |
regulation of integrin-mediated signaling pathway |
| Biological Process |
GO:0034097 |
response to cytokine |
| Biological Process |
GO:0009725 |
response to hormone |
| Biological Process |
GO:0043434 |
response to peptide hormone |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.