Search Results

Overview

Uniprot ID	P01042
Protein Name	Kininogen-1
Gene Name	KNG1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	CEYKDAAKAATGECT
113	ECTATVGKRSSTKFS
262	DFVQPPTKICVGCPR
315	RVQVVAGKKYFIDFV
343	LTESCETKKLGQSLD
43	AVDAALKKYNSQNQS
64	YRITEATKTVGSDTF
79	YSFKYEIKEGDCPVQ
97	TWQDCEYKDAAKAAT

Function

Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting

Protein Sequence

10 MKLITILFLC 20 SRLLLSLTQE 30 SQSEEIDCND 40 KDLFKAVDAA 50 LKKYNSQNQS 60 NNQFVLYRIT 70 EATKTVGSDT 80 FYSFKYEIKE 90 GDCPVQSGKT 100 WQDCEYKDAA 110 KAATGECTAT 120 VGKRSSTKFS 130 VATQTCQITP 140 AEGPVVTAQY 150 DCLGCVHPIS 160 TQSPDLEPIL 170 RHGIQYFNNN 180 TQHSSLFMLN 190 EVKRAQRQVV 200 AGLNFRITYS 210 IVQTNCSKEN 220 FLFLTPDCKS 230 LWNGDTGECT 240 DNAYIDIQLR 250 IASFSQNCDI 260 YPGKDFVQPP 270 TKICVGCPRD 280 IPTNSPELEE 290 TLTHTITKLN 300 AENNATFYFK 310 IDNVKKARVQ 320 VVAGKKYFID 330 FVARETTCSK 340 ESNEELTESC 350 ETKKLGQSLD 360 CNAEVYVVPW 370 EKKIYPTVNC 380 QPLGMISLMK 390 RPPGFSPFRS 400 SRIGEIKEET 410 TVSPPHTSMA 420 PAQDEERDSG 430 KEQGHTRRHD 440 WGHEKQRKHN 450 LGHGHKHERD 460 QGHGHQRGHG 470 LGHGHEQQHG 480 LGHGHKFKLD 490 DDLEHQGGHV 500 LDHGHKHKHG 510 HGHGKHKNKG 520 KKNGKHNGWK 530 TEHLASSSED 540 STTPSAQTQE 550 KTEGPTPIPS 560 LAKPGVTVTF 570 SDFQDSDLIA 580 TMMPPISPAP 590 IQSDDDWIPD 600 IQIDPNGLSF 610 NPISDFPDTT 620 SPKCPGRPWK 630 SVSEINPTTQ 640 MKESYYFDLT DGLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0031093	platelet alpha granule lumen
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0005179	hormone activity
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0007596	blood coagulation
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0030195	negative regulation of blood coagulation
Biological Process	GO:0007162	negative regulation of cell adhesion
Biological Process	GO:0045861	negative regulation of proteolysis
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration
Biological Process	GO:0042311	vasodilation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.