Search Results
Overview
| Uniprot ID | P01112 |
|---|---|
| Protein Name | GTPase HRas |
| Gene Name | HRAS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | VREIRQHKLRKLNPP |
Function
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
Protein Sequence
10
MTEYKLVVVG
20
AGGVGKSALT
30
IQLIQNHFVD
40
EYDPTIEDSY
50
RKQVVIDGET
60
CLLDILDTAG
70
QEEYSAMRDQ
80
YMRTGEGFLC
90
VFAINNTKSF
100
EDIHQYREQI
110
KRVKDSDDVP
120
MVLVGNKCDL
130
AARTVESRQA
140
QDLARSYGIP
150
YIETSAKTRQ
160
GVEDAFYTLV
170
REIRQHKLRK
180
LNPPDESGPG
CMSCKCVLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:2000630 | positive regulation of miRNA metabolic process |
| Biological Process | GO:0090314 | positive regulation of protein targeting to membrane |
| Biological Process | GO:0046579 | positive regulation of Ras protein signal transduction |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0014044 | Schwann cell development |
| Biological Process | GO:0007165 | signal transduction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0160185 | phospholipase C activator activity |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0009887 | animal organ morphogenesis |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.