Search Results
Overview
| Uniprot ID | P01116 |
|---|---|
| Protein Name | GTPase KRas |
| Gene Name | KRAS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | PMVLVGNKCDLPSRT |
| 128 | PSRTVDTKQAQDLAR |
Function
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22711838, PubMed:23698361). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0019002 | GMP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030275 | LRR domain binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Biological Process | GO:0060038 | cardiac muscle cell proliferation |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0051450 | myoblast proliferation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000774 | positive regulation of cellular senescence |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0046579 | positive regulation of Ras protein signal transduction |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0009629 | response to gravity |
| Biological Process | GO:0035900 | response to isolation stress |
| Biological Process | GO:0051385 | response to mineralocorticoid |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.