Search Results
Overview
| Uniprot ID | P01833 |
|---|---|
| Protein Name | Polymeric immunoglobulin receptor |
| Gene Name | PIGR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 231 | DDSNSNKKNADLQVL |
| 288 | VVVNTLGKRAPAFEG |
Function
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment
Protein Sequence
10
MLLFVLTCLL
20
AVFPAISTKS
30
PIFGPEEVNS
40
VEGNSVSITC
50
YYPPTSVNRH
60
TRKYWCRQGA
70
RGGCITLISS
80
EGYVSSKYAG
90
RANLTNFPEN
100
GTFVVNIAQL
110
SQDDSGRYKC
120
GLGINSRGLS
130
FDVSLEVSQG
140
PGLLNDTKVY
150
TVDLGRTVTI
160
NCPFKTENAQ
170
KRKSLYKQIG
180
LYPVLVIDSS
190
GYVNPNYTGR
200
IRLDIQGTGQ
210
LLFSVVINQL
220
RLSDAGQYLC
230
QAGDDSNSNK
240
KNADLQVLKP
250
EPELVYEDLR
260
GSVTFHCALG
270
PEVANVAKFL
280
CRQSSGENCD
290
VVVNTLGKRA
300
PAFEGRILLN
310
PQDKDGSFSV
320
VITGLRKEDA
330
GRYLCGAHSD
340
GQLQEGSPIQ
350
AWQLFVNEES
360
TIPRSPTVVK
370
GVAGGSVAVL
380
CPYNRKESKS
390
IKYWCLWEGA
400
QNGRCPLLVD
410
SEGWVKAQYE
420
GRLSLLEEPG
430
NGTFTVILNQ
440
LTSRDAGFYW
450
CLTNGDTLWR
460
TTVEIKIIEG
470
EPNLKVPGNV
480
TAVLGETLKV
490
PCHFPCKFSS
500
YEKYWCKWNN
510
TGCQALPSQD
520
EGPSKAFVNC
530
DENSRLVSLT
540
LNLVTRADEG
550
WYWCGVKQGH
560
FYGETAAVYV
570
AVEERKAAGS
580
RDVSLAKADA
590
APDEKVLDSG
600
FREIENKAIQ
610
DPRLFAEEKA
620
VADTRDQADG
630
SRASVDSGSS
640
EEQGGSSRAL
650
VSTLVPLGLV
660
LAVGAVAVGV
670
ARARHRKNVD
680
RVSIRSYRTD
690
ISMSDFENSR
700
EFGANDNMGA
710
SSITQETSLG
720
GKEEFVATTE
730
STTETKEPKK
740
AKRSSKEEAE
750
MAYKDFLLQS
760
STVAAEAQDG
PQEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0043235 | receptor complex |
| Cellular Component | GO:0071751 | secretory IgA immunoglobulin complex |
| Molecular Function | GO:0001790 | polymeric immunoglobulin binding |
| Molecular Function | GO:0001792 | polymeric immunoglobulin receptor activity |
| Molecular Function | GO:0004888 | transmembrane signaling receptor activity |
| Biological Process | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0038093 | Fc receptor signaling pathway |
| Biological Process | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor |
| Biological Process | GO:0043113 | receptor clustering |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.