Overview
| Uniprot ID | P01860 |
|---|
| Protein Name | Immunoglobulin heavy constant gamma 3 |
|---|
| Gene Name | IGHG3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 101 |
VDKRVELKTPLGDTT |
Function
Constant region of immunoglobulin (Ig) heavy chains. Igs are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors, which upon binding to a specific antigen trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs known as antibodies mediate the effector phase of humoral immunity by blocking the interaction of infectious antigens with cellular receptors (via the antigen-binding region) and eliciting effector mechanisms that lead to pathogen neutralization (via the constant region) (PubMed:17576170, PubMed:20176268, PubMed:22158414). The antigen-binding region is formed by the variable domain of one heavy chain paired with the variable domain of its associated light chain. Each Ig molecule has two antigen-binding sites with remarkable affinity for a particular antigen due to V-(D)-J rearrangement, somatic hypermutations and affinity maturation of the variable domains upon antigen exposure (PubMed:17576170, PubMed:20176268, PubMed:22158414). The constant region defines the Ig isotype that perform distinct sets of effector functions. B cells diversify and rearrange their Ig constant regions through class-switch recombination, a process by which the constant region is switched from one Ig isotype to another, namely from IgM and IgD to IgG, IgA and IgE (PubMed:17576170, PubMed:20176268, PubMed:22158414). The constant region of Ig gamma-3 (IgG3) isotype interacts (via the fragment crystallizable, Fc) with receptors on innate immune cells and the complement system to mediate humoral effector functions, including antibody-dependent cellular cytotoxicity or phagocytosis, complement-dependent cytotoxicity and inflammatory responses
Protein Sequence
10
ASTKGPSVFP
20
LAPCSRSTSG
30
GTAALGCLVK
40
DYFPEPVTVS
50
WNSGALTSGV
60
HTFPAVLQSS
70
GLYSLSSVVT
80
VPSSSLGTQT
90
YTCNVNHKPS
100
NTKVDKRVEL
110
KTPLGDTTHT
120
CPRCPEPKSC
130
DTPPPCPRCP
140
EPKSCDTPPP
150
CPRCPEPKSC
160
DTPPPCPRCP
170
APELLGGPSV
180
FLFPPKPKDT
190
LMISRTPEVT
200
CVVVDVSHED
210
PEVQFKWYVD
220
GVEVHNAKTK
230
PREEQYNSTF
240
RVVSVLTVLH
250
QDWLNGKEYK
260
CKVSNKALPA
270
PIEKTISKTK
280
GQPREPQVYT
290
LPPSREEMTK
300
NQVSLTCLVK
310
GFYPSDIAVE
320
WESSGQPENN
330
YNTTPPMLDS
340
DGSFFLYSKL
350
TVDKSRWQQG
360
NIFSCSVMHE
370
ALHNRFTQKS
380
LSLSPELQLE
390
ESCAEAQDGE
400
LDGLWTTITI
410
FITLFLLSVC
420
YSATVTFFKV
430
KWIFSSVVDL
440
KQTIIPDYRN
MIGQGA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0042571 |
immunoglobulin complex, circulating |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003823 |
antigen binding |
| Molecular Function |
GO:0034987 |
immunoglobulin receptor binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0019731 |
antibacterial humoral response |
| Biological Process |
GO:0050853 |
B cell receptor signaling pathway |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.