Overview
| Uniprot ID | P01871 |
|---|
| Protein Name | Immunoglobulin heavy constant mu |
|---|
| Gene Name | IGHM |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
FGNPRKSKLICQATG |
| 64 |
PSVLRGGKYAATSQV |
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)
Protein Sequence
10
GSASAPTLFP
20
LVSCENSPSD
30
TSSVAVGCLA
40
QDFLPDSITF
50
SWKYKNNSDI
60
SSTRGFPSVL
70
RGGKYAATSQ
80
VLLPSKDVMQ
90
GTDEHVVCKV
100
QHPNGNKEKN
110
VPLPVIAELP
120
PKVSVFVPPR
130
DGFFGNPRKS
140
KLICQATGFS
150
PRQIQVSWLR
160
EGKQVGSGVT
170
TDQVQAEAKE
180
SGPTTYKVTS
190
TLTIKESDWL
200
GQSMFTCRVD
210
HRGLTFQQNA
220
SSMCVPDQDT
230
AIRVFAIPPS
240
FASIFLTKST
250
KLTCLVTDLT
260
TYDSVTISWT
270
RQNGEAVKTH
280
TNISESHPNA
290
TFSAVGEASI
300
CEDDWNSGER
310
FTCTVTHTDL
320
PSPLKQTISR
330
PKGVALHRPD
340
VYLLPPAREQ
350
LNLRESATIT
360
CLVTGFSPAD
370
VFVQWMQRGQ
380
PLSPEKYVTS
390
APMPEPQAPG
400
RYFAHSILTV
410
SEEEWNTGET
420
YTCVVAHEAL
430
PNRVTERTVD
440
KSTEGEVSAD
450
EEGFENLWAT
460
ASTFIVLFLL
470
SLFYSTTVTL
FKVK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0071757 |
hexameric IgM immunoglobulin complex |
| Cellular Component |
GO:0071755 |
IgM B cell receptor complex |
| Cellular Component |
GO:0071756 |
pentameric IgM immunoglobulin complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003823 |
antigen binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0019731 |
antibacterial humoral response |
| Biological Process |
GO:0050853 |
B cell receptor signaling pathway |
| Biological Process |
GO:0050829 |
defense response to Gram-negative bacterium |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0002331 |
pre-B cell allelic exclusion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.