Search Results

Overview

Uniprot IDP01876
Protein NameImmunoglobulin heavy constant alpha 1
Gene NameIGHA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
212 TAAYPESKTPLTATL
258 LARGFSPKDVLVRWL
275 SQELPREKYLTWASR
307 VAAEDWKKGDTFSCM

Function

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915)

Protein Sequence

10 ASPTSPKVFP 20 LSLCSTQPDG 30 NVVIACLVQG 40 FFPQEPLSVT 50 WSESGQGVTA 60 RNFPPSQDAS 70 GDLYTTSSQL 80 TLPATQCLAG 90 KSVTCHVKHY 100 TNPSQDVTVP 110 CPVPSTPPTP 120 SPSTPPTPSP 130 SCCHPRLSLH 140 RPALEDLLLG 150 SEANLTCTLT 160 GLRDASGVTF 170 TWTPSSGKSA 180 VQGPPERDLC 190 GCYSVSSVLP 200 GCAEPWNHGK 210 TFTCTAAYPE 220 SKTPLTATLS 230 KSGNTFRPEV 240 HLLPPPSEEL 250 ALNELVTLTC 260 LARGFSPKDV 270 LVRWLQGSQE 280 LPREKYLTWA 290 SRQEPSQGTT 300 TFAVTSILRV 310 AAEDWKKGDT 320 FSCMVGHEAL 330 PLAFTQKTID 340 RLADWQMPPP 350 YVVLDLPQET 360 LEEETPGANL 370 WPTTITFLTL 380 FLLSLFYSTA 390 LTVTSVRGPS GNREGPQY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042571 immunoglobulin complex, circulating
Cellular Component GO:0071748 monomeric IgA immunoglobulin complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0071752 secretory dimeric IgA immunoglobulin complex
Cellular Component GO:0071751 secretory IgA immunoglobulin complex
Molecular Function GO:0003823 antigen binding
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0003094 glomerular filtration
Biological Process GO:0006955 immune response
Biological Process GO:0060267 positive regulation of respiratory burst

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.