Overview
| Uniprot ID | P01889 |
|---|
| Protein Name | HLA class I histocompatibility antigen, B alpha chain |
|---|
| Gene Name | HLA-B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 267 |
AGDRTFQKWAAVVVP |
| 292 |
VQHEGLPKPLTLRWE |
| 92 |
DRNTQIYKAQAQTDR |
Function
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227)
Protein Sequence
10
MLVMAPRTVL
20
LLLSAALALT
30
ETWAGSHSMR
40
YFYTSVSRPG
50
RGEPRFISVG
60
YVDDTQFVRF
70
DSDAASPREE
80
PRAPWIEQEG
90
PEYWDRNTQI
100
YKAQAQTDRE
110
SLRNLRGYYN
120
QSEAGSHTLQ
130
SMYGCDVGPD
140
GRLLRGHDQY
150
AYDGKDYIAL
160
NEDLRSWTAA
170
DTAAQITQRK
180
WEAAREAEQR
190
RAYLEGECVE
200
WLRRYLENGK
210
DKLERADPPK
220
THVTHHPISD
230
HEATLRCWAL
240
GFYPAEITLT
250
WQRDGEDQTQ
260
DTELVETRPA
270
GDRTFQKWAA
280
VVVPSGEEQR
290
YTCHVQHEGL
300
PKPLTLRWEP
310
SSQSTVPIVG
320
IVAGLAVLAV
330
VVIGAVVAAV
340
MCRRKSSGGK
350
GGSYSQAACS
360
DSAQGSDVSL
TA
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:2001198 |
regulation of dendritic cell differentiation |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0012507 |
ER to Golgi transport vesicle membrane |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0098553 |
lumenal side of endoplasmic reticulum membrane |
| Biological Process |
GO:0032655 |
regulation of interleukin-12 production |
| Biological Process |
GO:0032675 |
regulation of interleukin-6 production |
| Biological Process |
GO:0002715 |
regulation of natural killer cell mediated immunity |
| Biological Process |
GO:0002667 |
regulation of T cell anergy |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0042612 |
MHC class I protein complex |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0030667 |
secretory granule membrane |
| Molecular Function |
GO:0030881 |
beta-2-microglobulin binding |
| Molecular Function |
GO:0042605 |
peptide antigen binding |
| Molecular Function |
GO:0051087 |
protein-folding chaperone binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0046977 |
TAP binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0002486 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
| Biological Process |
GO:0002476 |
antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
| Biological Process |
GO:0002477 |
antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| Biological Process |
GO:0006952 |
defense response |
| Biological Process |
GO:0016045 |
detection of bacterium |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
| Biological Process |
GO:0042270 |
protection from natural killer cell mediated cytotoxicity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.