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Overview

Uniprot IDP02088
Protein NameHemoglobin subunit beta-1
Gene NameHbb-b1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
67 KVKAHGKKVITAFND
83 LNHLDSLKGTFASLS
96 LSELHCDKLHVDPEN

Function

Involved in oxygen transport from the lung to the various peripheral tissues

Protein Sequence

10 MVHLTDAEKA 20 AVSCLWGKVN 30 SDEVGGEALG 40 RLLVVYPWTQ 50 RYFDSFGDLS 60 SASAIMGNAK 70 VKAHGKKVIT 80 AFNDGLNHLD 90 SLKGTFASLS 100 ELHCDKLHVD 110 PENFRLLGNM 120 IVIVLGHHLG 130 KDFTPAAQAA 140 FQKVVAGVAT ALAHKYH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0031838 haptoglobin-hemoglobin complex
Cellular Component GO:0005833 hemoglobin complex
Cellular Component GO:0043209 myelin sheath
Molecular Function GO:0020037 heme binding
Molecular Function GO:0031721 hemoglobin alpha binding
Molecular Function GO:0031722 hemoglobin beta binding
Molecular Function GO:0030492 hemoglobin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0019825 oxygen binding
Molecular Function GO:0005344 oxygen carrier activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0015670 carbon dioxide transport
Biological Process GO:0098869 cellular oxidant detoxification
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0015671 oxygen transport
Biological Process GO:0010999 regulation of eIF2 alpha phosphorylation by heme

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.