Overview
| Uniprot ID | P02144 |
|---|
| Protein Name | Myoglobin |
|---|
| Gene Name | MB |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 141 |
KALELFRKDMASNYK |
| 148 |
KDMASNYKELGFQG* |
| 51 |
FDKFKHLKSEDEMKA |
| 88 |
GHHEAEIKPLAQSHA |
Function
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)
Protein Sequence
10
MGLSDGEWQL
20
VLNVWGKVEA
30
DIPGHGQEVL
40
IRLFKGHPET
50
LEKFDKFKHL
60
KSEDEMKASE
70
DLKKHGATVL
80
TALGGILKKK
90
GHHEAEIKPL
100
AQSHATKHKI
110
PVKYLEFISE
120
CIIQVLQSKH
130
PGDFGADAQG
140
AMNKALELFR
150
KDMASNYKEL
GFQG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0016528 |
sarcoplasm |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0098809 |
nitrite reductase activity |
| Molecular Function |
GO:0019825 |
oxygen binding |
| Molecular Function |
GO:0005344 |
oxygen carrier activity |
| Molecular Function |
GO:0004601 |
peroxidase activity |
| Biological Process |
GO:0015671 |
oxygen transport |
| Biological Process |
GO:0019430 |
removal of superoxide radicals |
| Biological Process |
GO:0003009 |
skeletal muscle contraction |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.