Search Results

Overview

Uniprot IDP02452
Protein NameCollagen alpha-1(I) chain
Gene NameCOL1A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1096 PQGPRGDKGETGEQG
237 GDDGEAGKPGRPGER
277 FSGLDGAKGDAGPAG
505 ADGVAGPKGPAGERG
586 VMGFPGPKGAAGEPG
594 GAAGEPGKAGERGVP
612 GAVGPAGKDGEAGAQ
751 DRGDAGPKGADGSPG
759 GADGSPGKDGVRGLT
907 PAGKEGGKGPRGETG
984 GPSGEPGKQGPSGAS

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen)

Protein Sequence

10 MFSFVDLRLL 20 LLLAATALLT 30 HGQEEGQVEG 40 QDEDIPPITC 50 VQNGLRYHDR 60 DVWKPEPCRI 70 CVCDNGKVLC 80 DDVICDETKN 90 CPGAEVPEGE 100 CCPVCPDGSE 110 SPTDQETTGV 120 EGPKGDTGPR 130 GPRGPAGPPG 140 RDGIPGQPGL 150 PGPPGPPGPP 160 GPPGLGGNFA 170 PQLSYGYDEK 180 STGGISVPGP 190 MGPSGPRGLP 200 GPPGAPGPQG 210 FQGPPGEPGE 220 PGASGPMGPR 230 GPPGPPGKNG 240 DDGEAGKPGR 250 PGERGPPGPQ 260 GARGLPGTAG 270 LPGMKGHRGF 280 SGLDGAKGDA 290 GPAGPKGEPG 300 SPGENGAPGQ 310 MGPRGLPGER 320 GRPGAPGPAG 330 ARGNDGATGA 340 AGPPGPTGPA 350 GPPGFPGAVG 360 AKGEAGPQGP 370 RGSEGPQGVR 380 GEPGPPGPAG 390 AAGPAGNPGA 400 DGQPGAKGAN 410 GAPGIAGAPG 420 FPGARGPSGP 430 QGPGGPPGPK 440 GNSGEPGAPG 450 SKGDTGAKGE 460 PGPVGVQGPP 470 GPAGEEGKRG 480 ARGEPGPTGL 490 PGPPGERGGP 500 GSRGFPGADG 510 VAGPKGPAGE 520 RGSPGPAGPK 530 GSPGEAGRPG 540 EAGLPGAKGL 550 TGSPGSPGPD 560 GKTGPPGPAG 570 QDGRPGPPGP 580 PGARGQAGVM 590 GFPGPKGAAG 600 EPGKAGERGV 610 PGPPGAVGPA 620 GKDGEAGAQG 630 PPGPAGPAGE 640 RGEQGPAGSP 650 GFQGLPGPAG 660 PPGEAGKPGE 670 QGVPGDLGAP 680 GPSGARGERG 690 FPGERGVQGP 700 PGPAGPRGAN 710 GAPGNDGAKG 720 DAGAPGAPGS 730 QGAPGLQGMP 740 GERGAAGLPG 750 PKGDRGDAGP 760 KGADGSPGKD 770 GVRGLTGPIG 780 PPGPAGAPGD 790 KGESGPSGPA 800 GPTGARGAPG 810 DRGEPGPPGP 820 AGFAGPPGAD 830 GQPGAKGEPG 840 DAGAKGDAGP 850 PGPAGPAGPP 860 GPIGNVGAPG 870 AKGARGSAGP 880 PGATGFPGAA 890 GRVGPPGPSG 900 NAGPPGPPGP 910 AGKEGGKGPR 920 GETGPAGRPG 930 EVGPPGPPGP 940 AGEKGSPGAD 950 GPAGAPGTPG 960 PQGIAGQRGV 970 VGLPGQRGER 980 GFPGLPGPSG 990 EPGKQGPSGA 1000 SGERGPPGPM 1010 GPPGLAGPPG 1020 ESGREGAPGA 1030 EGSPGRDGSP 1040 GAKGDRGETG 1050 PAGPPGAPGA 1060 PGAPGPVGPA 1070 GKSGDRGETG 1080 PAGPAGPVGP 1090 VGARGPAGPQ 1100 GPRGDKGETG 1110 EQGDRGIKGH 1120 RGFSGLQGPP 1130 GPPGSPGEQG 1140 PSGASGPAGP 1150 RGPPGSAGAP 1160 GKDGLNGLPG 1170 PIGPPGPRGR 1180 TGDAGPVGPP 1190 GPPGPPGPPG 1200 PPSAGFDFSF 1210 LPQPPQEKAH 1220 DGGRYYRADD 1230 ANVVRDRDLE 1240 VDTTLKSLSQ 1250 QIENIRSPEG 1260 SRKNPARTCR 1270 DLKMCHSDWK 1280 SGEYWIDPNQ 1290 GCNLDAIKVF 1300 CNMETGETCV 1310 YPTQPSVAQK 1320 NWYISKNPKD 1330 KRHVWFGESM 1340 TDGFQFEYGG 1350 QGSDPADVAI 1360 QLTFLRLMST 1370 EASQNITYHC 1380 KNSVAYMDQQ 1390 TGNLKKALLL 1400 QGSNEIEIRA 1410 EGNSRFTYSV 1420 TVDGCTSHTG 1430 AWGKTVIEYK 1440 TTKTSRLPII 1450 DVAPLDVGAP 1460 DQEFGFDVGP VCFL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005584 collagen type I trimer
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0030141 secretory granule
Molecular Function GO:0030020 extracellular matrix structural constituent conferring tensile strength
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0048407 platelet-derived growth factor binding
Molecular Function GO:0002020 protease binding
Biological Process GO:0001568 blood vessel development
Biological Process GO:1905641 cellular response to acetaldehyde
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0044344 cellular response to fibroblast growth factor stimulus
Biological Process GO:1902618 cellular response to fluoride
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0071306 cellular response to vitamin E
Biological Process GO:0032964 collagen biosynthetic process
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0048706 embryonic skeletal system development
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:0034504 protein localization to nucleus
Biological Process GO:0051591 response to cAMP
Biological Process GO:0032355 response to estradiol
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0055093 response to hyperoxia
Biological Process GO:0032868 response to insulin
Biological Process GO:0048545 response to steroid hormone
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0001501 skeletal system development
Biological Process GO:0043589 skin morphogenesis
Biological Process GO:0034505 tooth mineralization
Biological Process GO:0007601 visual perception

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.