Search Results
Overview
| Uniprot ID | P02454 |
|---|---|
| Protein Name | Collagen alpha-1(I) chain |
| Gene Name | Col1a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1308 | WYISPNPKEKKHVWF |
| 1374 | DQQTGNLKKSLLLQG |
| 1375 | QQTGNLKKSLLLQGS |
| 1419 | GKTVIEYKTTKTSRL |
| 77 | LDCPNPQKREGECCP |
Function
Type I collagen is a member of group I collagen (fibrillar forming collagen)
Protein Sequence
10
MFSFVDLRLL
20
LLLGATALLT
30
HGQEDIPEVS
40
CIHNGLRVPN
50
GETWKPDVCL
60
ICICHNGTAV
70
CDGVLCKEDL
80
DCPNPQKREG
90
ECCPFCPEEY
100
VSPDAEVIGV
110
EGPKGDPGPQ
120
GPRGPVGPPG
130
QDGIPGQPGL
140
PGPPGPPGPP
150
GPPGLGGNFA
160
SQMSYGYDEK
170
SAGVSVPGPM
180
GPSGPRGLPG
190
PPGAPGPQGF
200
QGPPGEPGEP
210
GASGPMGPRG
220
PPGPPGKNGD
230
DGEAGKPGRP
240
GERGPPGPQG
250
ARGLPGTAGL
260
PGMKGHRGFS
270
GLDGAKGDTG
280
PAGPKGEPGS
290
PGENGAPGQM
300
GPRGLPGERG
310
RPGPPGSAGA
320
RGNDGAVGAA
330
GPPGPTGPTG
340
PPGFPGAAGA
350
KGEAGPQGAR
360
GSEGPQGVRG
370
EPGPPGPAGA
380
AGPAGNPGAD
390
GQPGAKGANG
400
APGIAGAPGF
410
PGARGPSGPQ
420
GPSGAPGPKG
430
NSGEPGAPGN
440
KGDTGAKGEP
450
GPAGVQGPPG
460
PAGEEGKRGA
470
RGEPGPSGLP
480
GPPGERGGPG
490
SRGFPGADGV
500
AGPKGPAGER
510
GSPGPAGPKG
520
SPGEAGRPGE
530
AGLPGAKGLT
540
GSPGSPGPDG
550
KTGPPGPAGQ
560
DGRPGPAGPP
570
GARGQAGVMG
580
FPGPKGTAGE
590
PGKAGERGVP
600
GPPGAVGPAG
610
KDGEAGAQGA
620
PGPAGPAGER
630
GEQGPAGSPG
640
FQGLPGPAGP
650
PGEAGKPGEQ
660
GVPGDLGAPG
670
PSGARGERGF
680
PGERGVQGPP
690
GPAGPRGNNG
700
APGNDGAKGD
710
TGAPGAPGSQ
720
GAPGLQGMPG
730
ERGAAGLPGP
740
KGDRGDAGPK
750
GADGSPGKDG
760
VRGLTGPIGP
770
PGPAGAPGDK
780
GETGPSGPAG
790
PTGARGAPGD
800
RGEPGPPGPA
810
GFAGPPGADG
820
QPGAKGEPGD
830
TGVKGDAGPP
840
GPAGPAGPPG
850
PIGNVGAPGP
860
KGSRGAAGPP
870
GATGFPGAAG
880
RVGPPGPSGN
890
AGPPGPPGPV
900
GKEGGKGPRG
910
ETGPAGRPGE
920
VGPPGPPGPA
930
GEKGSPGADG
940
PAGSPGTPGP
950
QGIAGQRGVV
960
GLPGQRGERG
970
FPGLPGPSGE
980
PGKQGPSGAS
990
GERGPPGPMG
1000
PPGLAGPPGE
1010
SGREGSPGAE
1020
GSPGRDGAPG
1030
AKGDRGETGP
1040
AGPPGAPGAP
1050
GAPGPVGPAG
1060
KNGDRGETGP
1070
AGPAGPIGPA
1080
GARGPAGPQG
1090
PRGDKGETGE
1100
QGDRGIKGHR
1110
GFSGLQGPPG
1120
SPGSPGEQGP
1130
SGASGPAGPR
1140
GPPGSAGSPG
1150
KDGLNGLPGP
1160
IGPPGPRGRT
1170
GDSGPAGPPG
1180
PPGPPGPPGP
1190
PSGGYDFSFL
1200
PQPPQEKSQD
1210
GGRYYRADDA
1220
NVVRDRDLEV
1230
DTTLKSLSQQ
1240
IENIRSPEGS
1250
RKNPARTCRD
1260
LKMCHSDWKS
1270
GEYWIDPNQG
1280
CNLDAIKVYC
1290
NMETGQTCVF
1300
PTQPSVPQKN
1310
WYISPNPKEK
1320
KHVWFGESMT
1330
DGFQFEYGSE
1340
GSDPADVAIQ
1350
LTFLRLMSTE
1360
ASQNITYHCK
1370
NSVAYMDQQT
1380
GNLKKSLLLQ
1390
GSNEIELRGE
1400
GNSRFTYSTL
1410
VDGCTSHTGT
1420
WGKTVIEYKT
1430
TKTSRLPIID
1440
VAPLDIGAPD
1450
QEFGMDIGPA
CFV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005581 | collagen trimer |
| Cellular Component | GO:0005584 | collagen type I trimer |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030141 | secretory granule |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0030020 | extracellular matrix structural constituent conferring tensile strength |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0048407 | platelet-derived growth factor binding |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0001568 | blood vessel development |
| Biological Process | GO:0060346 | bone trabecula formation |
| Biological Process | GO:0060351 | cartilage development involved in endochondral bone morphogenesis |
| Biological Process | GO:1905641 | cellular response to acetaldehyde |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:1902618 | cellular response to fluoride |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0071306 | cellular response to vitamin E |
| Biological Process | GO:0032964 | collagen biosynthetic process |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| Biological Process | GO:0048706 | embryonic skeletal system development |
| Biological Process | GO:0001958 | endochondral ossification |
| Biological Process | GO:0060325 | face morphogenesis |
| Biological Process | GO:0001957 | intramembranous ossification |
| Biological Process | GO:0010812 | negative regulation of cell-substrate adhesion |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:1902617 | response to fluoride |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0055093 | response to hyperoxia |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0048545 | response to steroid hormone |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007605 | sensory perception of sound |
| Biological Process | GO:0001501 | skeletal system development |
| Biological Process | GO:0048705 | skeletal system morphogenesis |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0043589 | skin morphogenesis |
| Biological Process | GO:0034505 | tooth mineralization |
| Biological Process | GO:0007601 | visual perception |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.