Search Results

Overview

Uniprot ID	P02461
Protein Name	Collagen alpha-1(III) chain
Gene Name	COL3A1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1106	ERGAAGIKGHRGFPG
743	SPGPKGDKGEPGGPG
757	GADGVPGKDGPRGPT
982	GVKGESGKPGANGLS

Function

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12

Protein Sequence

10 MMSFVQKGSW 20 LLLALLHPTI 30 ILAQQEAVEG 40 GCSHLGQSYA 50 DRDVWKPEPC 60 QICVCDSGSV 70 LCDDIICDDQ 80 ELDCPNPEIP 90 FGECCAVCPQ 100 PPTAPTRPPN 110 GQGPQGPKGD 120 PGPPGIPGRN 130 GDPGIPGQPG 140 SPGSPGPPGI 150 CESCPTGPQN 160 YSPQYDSYDV 170 KSGVAVGGLA 180 GYPGPAGPPG 190 PPGPPGTSGH 200 PGSPGSPGYQ 210 GPPGEPGQAG 220 PSGPPGPPGA 230 IGPSGPAGKD 240 GESGRPGRPG 250 ERGLPGPPGI 260 KGPAGIPGFP 270 GMKGHRGFDG 280 RNGEKGETGA 290 PGLKGENGLP 300 GENGAPGPMG 310 PRGAPGERGR 320 PGLPGAAGAR 330 GNDGARGSDG 340 QPGPPGPPGT 350 AGFPGSPGAK 360 GEVGPAGSPG 370 SNGAPGQRGE 380 PGPQGHAGAQ 390 GPPGPPGING 400 SPGGKGEMGP 410 AGIPGAPGLM 420 GARGPPGPAG 430 ANGAPGLRGG 440 AGEPGKNGAK 450 GEPGPRGERG 460 EAGIPGVPGA 470 KGEDGKDGSP 480 GEPGANGLPG 490 AAGERGAPGF 500 RGPAGPNGIP 510 GEKGPAGERG 520 APGPAGPRGA 530 AGEPGRDGVP 540 GGPGMRGMPG 550 SPGGPGSDGK 560 PGPPGSQGES 570 GRPGPPGPSG 580 PRGQPGVMGF 590 PGPKGNDGAP 600 GKNGERGGPG 610 GPGPQGPPGK 620 NGETGPQGPP 630 GPTGPGGDKG 640 DTGPPGPQGL 650 QGLPGTGGPP 660 GENGKPGEPG 670 PKGDAGAPGA 680 PGGKGDAGAP 690 GERGPPGLAG 700 APGLRGGAGP 710 PGPEGGKGAA 720 GPPGPPGAAG 730 TPGLQGMPGE 740 RGGLGSPGPK 750 GDKGEPGGPG 760 ADGVPGKDGP 770 RGPTGPIGPP 780 GPAGQPGDKG 790 EGGAPGLPGI 800 AGPRGSPGER 810 GETGPPGPAG 820 FPGAPGQNGE 830 PGGKGERGAP 840 GEKGEGGPPG 850 VAGPPGGSGP 860 AGPPGPQGVK 870 GERGSPGGPG 880 AAGFPGARGL 890 PGPPGSNGNP 900 GPPGPSGSPG 910 KDGPPGPAGN 920 TGAPGSPGVS 930 GPKGDAGQPG 940 EKGSPGAQGP 950 PGAPGPLGIA 960 GITGARGLAG 970 PPGMPGPRGS 980 PGPQGVKGES 990 GKPGANGLSG 1000 ERGPPGPQGL 1010 PGLAGTAGEP 1020 GRDGNPGSDG 1030 LPGRDGSPGG 1040 KGDRGENGSP 1050 GAPGAPGHPG 1060 PPGPVGPAGK 1070 SGDRGESGPA 1080 GPAGAPGPAG 1090 SRGAPGPQGP 1100 RGDKGETGER 1110 GAAGIKGHRG 1120 FPGNPGAPGS 1130 PGPAGQQGAI 1140 GSPGPAGPRG 1150 PVGPSGPPGK 1160 DGTSGHPGPI 1170 GPPGPRGNRG 1180 ERGSEGSPGH 1190 PGQPGPPGPP 1200 GAPGPCCGGV 1210 GAAAIAGIGG 1220 EKAGGFAPYY 1230 GDEPMDFKIN 1240 TDEIMTSLKS 1250 VNGQIESLIS 1260 PDGSRKNPAR 1270 NCRDLKFCHP 1280 ELKSGEYWVD 1290 PNQGCKLDAI 1300 KVFCNMETGE 1310 TCISANPLNV 1320 PRKHWWTDSS 1330 AEKKHVWFGE 1340 SMDGGFQFSY 1350 GNPELPEDVL 1360 DVHLAFLRLL 1370 SSRASQNITY 1380 HCKNSIAYMD 1390 QASGNVKKAL 1400 KLMGSNEGEF 1410 KAEGNSKFTY 1420 TVLEDGCTKH 1430 TGEWSKTVFE 1440 YRTRKAVRLP 1450 IVDIAPYDIG 1460 GPDQEFGVDV GPVCFL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005586	collagen type III trimer
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0048407	platelet-derived growth factor binding
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0046332	SMAD binding
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis
Biological Process	GO:0071711	basement membrane organization
Biological Process	GO:0007160	cell-matrix adhesion
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0002062	chondrocyte differentiation
Biological Process	GO:0030199	collagen fibril organization
Biological Process	GO:0048251	elastic fiber assembly
Biological Process	GO:0060350	endochondral bone morphogenesis
Biological Process	GO:0048144	fibroblast proliferation
Biological Process	GO:0007507	heart development
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0021819	layer formation in cerebral cortex
Biological Process	GO:0036022	limb joint morphogenesis
Biological Process	GO:0030324	lung development
Biological Process	GO:0035264	multicellular organism growth
Biological Process	GO:0050777	negative regulation of immune response
Biological Process	GO:2001223	negative regulation of neuron migration
Biological Process	GO:0001764	neuron migration
Biological Process	GO:0018149	peptide cross-linking
Biological Process	GO:0030168	platelet activation
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction
Biological Process	GO:1990776	response to angiotensin
Biological Process	GO:0034097	response to cytokine
Biological Process	GO:0009314	response to radiation
Biological Process	GO:0048705	skeletal system morphogenesis
Biological Process	GO:0043588	skin development
Biological Process	GO:0097435	supramolecular fiber organization
Biological Process	GO:0001894	tissue homeostasis
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
Biological Process	GO:0032905	transforming growth factor beta1 production
Biological Process	GO:0042060	wound healing

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.