Search Results
Overview
| Uniprot ID | P02511 |
|---|---|
| Protein Name | Alpha-crystallin B chain |
| Gene Name | CRYAB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | DVIEVHGKHEERQDE |
| 150 | LTVNGPRKQVSGPER |
| 166 | IPITREEKPAVTAAP |
| 174 | PAVTAAPKK****** |
| 82 | FSVNLDVKHFSPEEL |
| 90 | HFSPEELKVKVLGDV |
| 92 | SPEELKVKVLGDVIE |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032432 | actin filament bundle |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0031109 | microtubule polymerization or depolymerization |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0032387 | negative regulation of intracellular transport |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0043067 | regulation of programmed cell death |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.