Overview
| Uniprot ID | P02533 |
|---|
| Protein Name | Keratin, type I cytoskeletal 14 |
|---|
| Gene Name | KRT14 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 132 |
RLASYLDKVRALEEA |
| 15 |
FTSSSSMKGSCGIGG |
| 175 |
TIEDLRNKILTATVD |
Function
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms obligate heteropolymers with the type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and structural integrity to the basal layer of the epidermis and other stratified epithelial (PubMed:11724817, PubMed:1694855, PubMed:1720261). The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (PubMed:11724817)
Protein Sequence
10
MTTCSRQFTS
20
SSSMKGSCGI
30
GGGIGGGSSR
40
ISSVLAGGSC
50
RAPSTYGGGL
60
SVSSSRFSSG
70
GACGLGGGYG
80
GGFSSSSSSF
90
GSGFGGGYGG
100
GLGAGLGGGF
110
GGGFAGGDGL
120
LVGSEKVTMQ
130
NLNDRLASYL
140
DKVRALEEAN
150
ADLEVKIRDW
160
YQRQRPAEIK
170
DYSPYFKTIE
180
DLRNKILTAT
190
VDNANVLLQI
200
DNARLAADDF
210
RTKYETELNL
220
RMSVEADING
230
LRRVLDELTL
240
ARADLEMQIE
250
SLKEELAYLK
260
KNHEEEMNAL
270
RGQVGGDVNV
280
EMDAAPGVDL
290
SRILNEMRDQ
300
YEKMAEKNRK
310
DAEEWFFTKT
320
EELNREVATN
330
SELVQSGKSE
340
ISELRRTMQN
350
LEIELQSQLS
360
MKASLENSLE
370
ETKGRYCMQL
380
AQIQEMIGSV
390
EEQLAQLRCE
400
MEQQNQEYKI
410
LLDVKTRLEQ
420
EIATYRRLLE
430
GEDAHLSSSQ
440
FSSGSQSSRD
450
VTSSSRQIRT
460
KVMDVHDGKV
470
VSTHEQVLRT
KN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0045178 |
basal part of cell |
| Cellular Component |
GO:0001533 |
cornified envelope |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
| Cellular Component |
GO:0045095 |
keratin filament |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:1990254 |
keratin filament binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Molecular Function |
GO:0030280 |
structural constituent of skin epidermis |
| Biological Process |
GO:0008544 |
epidermis development |
| Biological Process |
GO:0042633 |
hair cycle |
| Biological Process |
GO:0045110 |
intermediate filament bundle assembly |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0030216 |
keratinocyte differentiation |
| Biological Process |
GO:0002009 |
morphogenesis of an epithelium |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.