Overview
| Uniprot ID | P02540 |
|---|
| Protein Name | Desmin |
|---|
| Gene Name | DES |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 126 |
RFANYIEKVRFLEQQ |
| 242 |
EEIAFLKKVHEEEIR |
| 300 |
AEEWYKSKVSDLTQA |
| 310 |
DLTQAANKNNDALRQ |
| 43 |
PRAGFGTKGSSSSVT |
Function
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin
Protein Sequence
10
MSQAYSSSQR
20
VSSYRRTFGG
30
APSFPLGSPL
40
SSPVFPRAGF
50
GTKGSSSSVT
60
SRVYQVSRTS
70
GGAGGLGPLR
80
ASRLGATRVP
90
SSSYGAGELL
100
DFSLADAVNQ
110
EFLTTRTNEK
120
VELQELNDRF
130
ANYIEKVRFL
140
EQQNAALAAE
150
VNRLKGREPT
160
RVAEIYEEEL
170
RELRRQVEVL
180
TNQRARVDVE
190
RDNLLDDLQR
200
LKAKLQEEIQ
210
LKEEAENNLA
220
AFRADVDAAT
230
LARIDLERRI
240
ESLNEEIAFL
250
KKVHEEEIRE
260
LQAQLQEQQV
270
QVEMDMSKPD
280
LTAALRDIRA
290
QYETIAAKNI
300
SEAEEWYKSK
310
VSDLTQAANK
320
NNDALRQAKQ
330
EMMEYRHQIQ
340
SYTCEIDALK
350
GTNDSLMRQM
360
RELEDRFASE
370
ASGYQDNIAR
380
LEEEIRHLKD
390
EMARHLREYQ
400
DLLNVKMALD
410
VEIATYRKLL
420
EGEESRINLP
430
IQTFSALNFR
440
ETSPEQRGSE
450
VHTKKTVMIK
460
TIETRDGEVV
470
SEATQQQHEV
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097512 |
cardiac myofibril |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005916 |
fascia adherens |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0031594 |
neuromuscular junction |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0006998 |
nuclear envelope organization |
| Biological Process |
GO:0060538 |
skeletal muscle organ development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.