Overview
| Uniprot ID | P02543 |
|---|
| Protein Name | Vimentin |
|---|
| Gene Name | VIM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 104 |
KNTRTNEKVELQELN |
| 120 |
RFANYIDKVRFLEQQ |
| 139 |
LAELEQLKGQGKSRL |
| 168 |
VDQLTNDKARVEVER |
| 188 |
DIMRLREKLQEETLQ |
| 223 |
ARLDLERKVESLQEE |
| 235 |
QEEIAFLKKLHDEEI |
| 282 |
QYESVAAKNLQEAEE |
| 292 |
QEAEEWYKSKFADLS |
| 294 |
AEEWYKSKFADLSEA |
| 313 |
NDALRQAKQESNEYR |
| 334 |
TCEVDALKGTNESLE |
| 373 |
QDEIQNMKEEMARHL |
| 402 |
IEIATYRKLLEGEES |
| 439 |
PLVDTHSKRTLLIKT |
| 445 |
SKRTLLIKTVETRDG |
Function
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)
Protein Sequence
10
MSTRTVSSSS
20
YRRMFGGPGT
30
ASRPSSSRSY
40
VTTSTRTYSL
50
GSALRPSTSR
60
SLYTSSPGGV
70
YATRSSAVRL
80
RSSVPGVRLL
90
QDAVDFSLAD
100
AINTEFKNTR
110
TNEKVELQEL
120
NDRFANYIDK
130
VRFLEQQNKI
140
LLAELEQLKG
150
QGKSRLGDLY
160
EEEMRELRRQ
170
VDQLTNDKAR
180
VEVERDNLAE
190
DIMRLREKLQ
200
EETLQREEAE
210
STLQSFRQDV
220
DNASLARLDL
230
ERKVESLQEE
240
IAFLKKLHDE
250
EIQELQAQIQ
260
EQHVQIDMDV
270
SKPDLTAALR
280
DVRQQYESVA
290
AKNLQEAEEW
300
YKSKFADLSE
310
AANRNNDALR
320
QAKQESNEYR
330
RQVQSLTCEV
340
DALKGTNESL
350
ERQMREMEEN
360
FAVEAANYQD
370
TIGRLQDEIQ
380
NMKEEMARHL
390
REYQDLLNVK
400
MALDIEIATY
410
RKLLEGEESR
420
ISLPLPNFSS
430
LNLRETNLES
440
LPLVDTHSKR
450
TLLIKTVETR
460
DGQVINETSQ
HHDDLE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0071225 |
cellular response to muramyl dipeptide |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0010634 |
positive regulation of epithelial cell migration |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.